PMID- 25263068
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20220330
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 4
DP  - 2014 Sep 29
TI  - Cell-based therapy for acute and chronic liver failures: distinct diseases, 
      different choices.
PG  - 6494
LID - 10.1038/srep06494 [doi]
LID - 6494
AB  - Cell-based therapies (CBTs) are considered the effective approaches to treat 
      liver failure. However, which cell type is the most suitable source of CBTs for 
      acute liver failure (ALF) or chronic liver failure (CLF) remains unclear. To 
      investigate this, mature hepatocytes in adult liver (adult HCs), fetal liver 
      cells (FLCs), induced hepatic stem cells (iHepSCs) and bone marrow derived 
      mesenchymal stromal cells (BMSCs) were used to CBTs for ConA-induced ALF and 
      Fah-deficient induced CLF in mice. The results showed that only BMSCs remitted 
      liver damage and rescued ALF in ConA-treated mice. In this process, BMSCs 
      inhibited ConA-induced inflammatory response by decreasing the mRNA expressions 
      of TNF-alpha, IFN-gamma and FasL and increasing IL-10 mRNA expression. However, in the 
      CLF model, not BMSCs but adult HCs transplantation lessened liver injury, 
      recovered liver function and rescued the life of Fah-/- mice after NTBC 
      withdrawal. Further study showed that adult HCs offered more effective liver 
      regeneration compared to other cells in Fah-/- mice without NTBC. These results 
      demonstrated that BMSCs and adult HCs are the optimal sources of CBTs for 
      ConA-induced ALF and Fah-deficient induced CLF in mice, respectively. This 
      finding deepens our understanding about how to select a proper CBT for different 
      liver failure.
FAU - Sun, Kai
AU  - Sun K
AD  - Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Xie, Xuqin
AU  - Xie X
AD  - 1] Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery 
      Hospital, The Second Military Medical University, Shanghai, China [2] Department 
      of Medical Biotechnology and Translational Medicine, University of Milan, Milan, 
      Italy.
FAU - Xie, Jing
AU  - Xie J
AD  - Department of Gynecology, Shanghai Tianshan Hospital, Shanghai, China.
FAU - Jiao, Shufan
AU  - Jiao S
AD  - Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Chen, Xiaojing
AU  - Chen X
AD  - Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Zhao, Xue
AU  - Zhao X
AD  - Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wang, Xin
AU  - Wang X
AD  - 1] The Key Laboratory of National Education Ministry for Mammalian Reproductive 
      Biology and Biotechnology, Inner Mongolia University, Huhhot, P.R.China [2] 
      Department of Laboratory Medicine and Pathology, University of Minnesota, 
      Minneapolis, Minnesota, MN, USA [3] Hepatoscience Incorporation, Palo Alto, CA.
FAU - Wei, Lixin
AU  - Wei L
AD  - 1] Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China [2] Tumor Immunology and Gene Therapy Center, Eastern 
      Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140929
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 11028-71-0 (Concanavalin A)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - *Cell- and Tissue-Based Therapy
MH  - Concanavalin A/toxicity
MH  - End Stage Liver Disease/chemically induced/pathology/*therapy
MH  - Hepatocytes/transplantation
MH  - Liver Failure, Acute/chemically induced/pathology/*therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology
MH  - Mice
PMC - PMC4178291
EDAT- 2014/09/30 06:00
MHDA- 2016/03/22 06:00
PMCR- 2014/09/29
CRDT- 2014/09/30 06:00
PHST- 2014/06/10 00:00 [received]
PHST- 2014/09/08 00:00 [accepted]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
PHST- 2014/09/29 00:00 [pmc-release]
AID - srep06494 [pii]
AID - 10.1038/srep06494 [doi]
PST - epublish
SO  - Sci Rep. 2014 Sep 29;4:6494. doi: 10.1038/srep06494.