PMID- 25263371
OWN - NLM
STAT- MEDLINE
DCOM- 20150913
LR  - 20220330
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 34
IP  - 9
DP  - 2014 Aug
TI  - [Effect of compound Danshen dripping pills combined with atorvastatin on 
      restenosis after angioplasty in rabbits].
PG  - 1337-41
AB  - OBJECTIVE: To study the effect of compound Danshen dripping pills and 
      atorvastatin on restenosis after abdominal aorta angioplasty in rabbits. METHODS: 
      Rabbit models of abdominal aorta restenosis after angioplasty were established 
      and treated with saline (group A), compound Danshen dripping pills (group B), 
      atorvastatin (group C), or compound Danshen dripping pills plus atorvastatin 
      (group D). HE staining was used to determine the thickness of arterial intimal 
      hyperplasia and assess the morphological changes of the narrowed artery. 
      Immunohistochemistry was employed to detect the expression of nuclear factor-kappaB 
      (NF-kappaB) and monocyte chemoattractant protein-1 (MCP-1). RESULTS: Compared with 
      group A, the 3 treatment groups showed significant increased vascular cavity area 
      and reduced intimal area and percentage of intimal hyperplasia (P<0.05). The 
      vascular cavity area, intimal area and percentage of intimal hyperplasia levels 
      differed significantly between group D and groups B and C (P<0.05). 
      Immunohistochemistry showed a significant reduction of the expression rate of 
      NF-kappaB and MCP-1 in the 3 treatment groups compared with group A (P<0.05), and the 
      reduction was especially obvious in group D (P<0.05). CONCLUTIONS: Compound 
      danshen dripping pills combined with atorvastatin produces better effects than 
      the drugs used alone in inhibiting vascular smooth muscle cell proliferation in 
      rabbits after abdominal aorta angioplasty possibly due to a decreased expression 
      of MCP-1 as a result of NF-kappaB inhibition.
FAU - Song, Jieli
AU  - Song J
AD  - Department of Cardiology of The Fifth Affiliated Hospital of Southern Medical, 
      Guangzhou 510900 China. E-mail: mf-422@163.com.
FAU - Zeng, Jinpei
AU  - Zeng J
FAU - Zhang, Yongxia
AU  - Zhang Y
FAU - Li, Pengfei
AU  - Li P
FAU - Zhang, Lihong
AU  - Zhang L
FAU - Chen, Cibin
AU  - Chen C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Heptanoic Acids)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenanthrolines)
RN  - 0 (Pyrroles)
RN  - 1693AM5SBN (dan-shen root extract)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
MH  - *Angioplasty
MH  - Animals
MH  - Aorta/*pathology
MH  - Atorvastatin
MH  - Cell Proliferation
MH  - Chemokine CCL2/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Heptanoic Acids/*pharmacology
MH  - Hyperplasia
MH  - Myocytes, Smooth Muscle/drug effects
MH  - NF-kappa B/metabolism
MH  - Phenanthrolines
MH  - Pyrroles/*pharmacology
MH  - Rabbits
MH  - Salvia miltiorrhiza/chemistry
MH  - Tunica Intima
EDAT- 2014/09/30 06:00
MHDA- 2015/09/14 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/09/14 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2014 Aug;34(9):1337-41.