PMID- 25264157 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20141202 IS - 1873-2747 (Electronic) IS - 0361-9230 (Linking) VI - 108 DP - 2014 Sep TI - Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease. PG - 106-12 LID - S0361-9230(14)00142-7 [pii] LID - 10.1016/j.brainresbull.2014.09.006 [doi] AB - Depression is a neuropsychiatric disorder that is commonly found in patients with Parkinson's disease (PD). Many studies have suggested that physical exercise can have an antidepressant effect by increasing the levels of brain-derived neurotrophic factor (BDNF), and may also prevent neurodegenerative disease. However, different forms of training may promote different changes in the brain. The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior, and on the levels of proBDNF, BDNF, and its receptor, TrkB, in a mouse model of PD. C57BL/6 mice were subjected to 60 days of exercise: either running on a treadmill or performing a strength exercise. PD was induced by striatal administration of 6-OHDA 24h after the last physical exercise session. Seven days after 6-OHDA injection, depressive-like behavior and apomorphine-induced rotational behavior were evaluated. The levels of proBDNF, BDNF, and TRKB were measured in the striatum and the hippocampus of mice by immunoblotting assay. The 6-OHDA-treated animals showed a significant increase in immobility time and rotational behavior compared with the control group. In addition, significant decreases in the levels of proBDNF, BDNF, and its receptor, TrkB were observed in the 6-OHDA group. Both types of physical exercise prevented depressive-like behavior and restored the levels of proBDNF, BDNF, and TrkB in the striatum and hippocampus of mice administered 6-OHDA. Our results demonstrate that exercise training was effective for neuroprotection in the striatum and the hippocampus in an experimental model of PD. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Tuon, T AU - Tuon T AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Valvassori, S S AU - Valvassori SS AD - Laboratory of Neurosciences, National Institute for Translational Medicine (INCT-TM), Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Dal Pont, G C AU - Dal Pont GC AD - Laboratory of Neurosciences, National Institute for Translational Medicine (INCT-TM), Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Paganini, C S AU - Paganini CS AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Pozzi, B G AU - Pozzi BG AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Luciano, T F AU - Luciano TF AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Souza, P S AU - Souza PS AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Quevedo, J AU - Quevedo J AD - Laboratory of Neurosciences, National Institute for Translational Medicine (INCT-TM), Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Souza, C T AU - Souza CT AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. FAU - Pinho, R A AU - Pinho RA AD - Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciuma, Santa Catarina 88806-000, Brazil. Electronic address: pinho@unesc.net. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140928 PL - United States TA - Brain Res Bull JT - Brain research bulletin JID - 7605818 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 8HW4YBZ748 (Oxidopamine) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Depression/etiology/*metabolism/*prevention & control MH - Disease Models, Animal MH - *Exercise Therapy MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Motor Activity MH - Oxidopamine/toxicity MH - Parkinson Disease/complications/*metabolism MH - Receptor, trkB/metabolism OTO - NOTNLM OT - 6-Hydroxydopamine OT - Depression OT - Neurotrophins OT - Parkinson's disease OT - Physical exercise EDAT- 2014/09/30 06:00 MHDA- 2015/07/17 06:00 CRDT- 2014/09/30 06:00 PHST- 2014/05/09 00:00 [received] PHST- 2014/07/30 00:00 [revised] PHST- 2014/09/16 00:00 [accepted] PHST- 2014/09/30 06:00 [entrez] PHST- 2014/09/30 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] AID - S0361-9230(14)00142-7 [pii] AID - 10.1016/j.brainresbull.2014.09.006 [doi] PST - ppublish SO - Brain Res Bull. 2014 Sep;108:106-12. doi: 10.1016/j.brainresbull.2014.09.006. Epub 2014 Sep 28.