PMID- 25264166
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20220331
IS  - 1873-2364 (Electronic)
IS  - 0960-8966 (Linking)
VI  - 24
IP  - 12
DP  - 2014 Dec
TI  - Swallowing assessment in myotonic dystrophy type 1 using fiberoptic endoscopic 
      evaluation of swallowing (FEES).
PG  - 1054-62
LID - S0960-8966(14)00152-7 [pii]
LID - 10.1016/j.nmd.2014.06.002 [doi]
AB  - This study describes the swallowing function of patients with myotonic dystrophy 
      type 1 (DM1) and the effect of bolus consistency on swallowing in this group. The 
      aim of the study is twofold: (a) to identify which (and to what extent) 
      swallowing variables change for DM1 patients relative to healthy control subjects 
      and (b) to examine whether the degree of oropharyngeal dysphagia is associated 
      with disease severity. Forty-five consecutive DM1 patients and ten healthy 
      subjects underwent a swallowing assessment, at Maastricht University medical 
      Center in the Netherlands. The assessment included a standardized fiberoptic 
      endoscopic evaluation of swallowing (FEES) protocol using different bolus 
      consistencies. Clinical severity of the disease was assessed using the muscular 
      impairment rating scale (MIRS). Significant differences were found between 
      patients and controls for all FEES variables. The magnitude of these differences 
      depended on the bolus consistency. The odds of a more pathological swallowing 
      outcome increased significantly with higher MIRS levels. In conclusion, 
      swallowing function is found to be significantly altered in DM1 patients. The 
      results emphasize the importance of conducting a detailed swallowing assessment 
      in all patients, even those with mild muscle weakness.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Pilz, Walmari
AU  - Pilz W
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, The Netherlands. Electronic address: w.pilz@mumc.nl.
FAU - Baijens, Laura W J
AU  - Baijens LW
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, The Netherlands.
FAU - Passos, Valeria Lima
AU  - Passos VL
AD  - Department of Methodology and Statistics, Maastricht University, Maastricht, The 
      Netherlands.
FAU - Verdonschot, Rob
AU  - Verdonschot R
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, The Netherlands; Emergency Department, Erasmus 
      Medical Center, Rotterdam, The Netherlands.
FAU - Wesseling, Frederik
AU  - Wesseling F
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, The Netherlands; Department of Radiation Oncology 
      (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht 
      University Medical Center, The Netherlands.
FAU - Roodenburg, Nel
AU  - Roodenburg N
AD  - Department of Neurology, Maastricht University Medical Center, Maastricht, The 
      Netherlands.
FAU - Faber, Catharina G
AU  - Faber CG
AD  - Department of Neurology, Maastricht University Medical Center, Maastricht, The 
      Netherlands.
FAU - Kremer, Bernd
AU  - Kremer B
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20140610
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
SB  - IM
MH  - Adult
MH  - Aged
MH  - Deglutition/*physiology
MH  - Deglutition Disorders/diagnosis/*physiopathology
MH  - Endoscopy/*methods
MH  - Female
MH  - Fiber Optic Technology/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myotonic Dystrophy/diagnosis/*physiopathology
MH  - Pharynx/physiopathology
MH  - Physical Stimulation/methods
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Deglutition
OT  - Deglutition disorders
OT  - Dysphagia
OT  - Fiberoptic endoscopic evaluation of swallowing
OT  - Myotonic dystrophy type 1
EDAT- 2014/09/30 06:00
MHDA- 2015/07/28 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/05/06 00:00 [revised]
PHST- 2014/06/01 00:00 [accepted]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
AID - S0960-8966(14)00152-7 [pii]
AID - 10.1016/j.nmd.2014.06.002 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2014 Dec;24(12):1054-62. doi: 10.1016/j.nmd.2014.06.002. Epub 
      2014 Jun 10.