PMID- 25264289
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20220311
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Print)
IS  - 1562-2975 (Linking)
VI  - 16
IP  - 3
DP  - 2015 Apr
TI  - Investigation of the genetic interaction between BDNF and DRD3 genes in 
      suicidical behaviour in psychiatric disorders.
PG  - 171-9
LID - 10.3109/15622975.2014.953011 [doi]
AB  - OBJECTIVES: Suicide is a serious public health concern, and it is partly genetic. 
      The brain-derived neurotrophic factor (BDNF) gene has been a strong candidate in 
      genetic studies of suicide (Dwivedi et al., Arch Gen Psychiatry 2010;60:804-815; 
      Zai et al., Prog Neuropsychopharmacol Biol Psychiatry 2012;34:1412-1418) and BDNF 
      regulates the expression of the dopamine D3 receptor. OBJECTIVE: We examined the 
      role of the BDNF and DRD3 genes in suicide. METHODS: We analysed four tag 
      single-nucleotide polymorphisms (SNPs) in BDNF and 15 SNPs in the D3 receptor 
      gene DRD3 for possible association with suicide attempt history in our Canadian 
      sample of Schizophrenia (SCZ) patients of European ancestry (N = 188). RESULTS: 
      In this sample, we found a possible interaction between the BDNF Val66Met and 
      DRD3 Ser9Gly SNPs in increasing the risk of suicide attempt(s) in our SCZ sample. 
      Specifically, a larger proportion of SCZ patients who were carrying at least one 
      copy of the minor allele at each of the Val66Met and Ser9Gly functional markers 
      have attempted suicides compared to patients with other genotypes (Bonferroni P < 
      0.05). However, we could not replicate this finding in samples from other 
      psychiatric populations. CONCLUSIONS: Taken together, the results from the 
      present study suggest that an interaction between BDNF and DRD3 may not play a 
      major role in the risk for suicide attempt, though further studies, especially in 
      SCZ, are required.
FAU - Zai, Clement C
AU  - Zai CC
AD  - Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre 
      for Addiction and Mental Health (CAMH) , Toronto, Ontario , Canada.
FAU - Manchia, Mirko
AU  - Manchia M
FAU - Sonderby, Ida Elken
AU  - Sonderby IE
FAU - Yilmaz, Zeynep
AU  - Yilmaz Z
FAU - De Luca, Vincenzo
AU  - De Luca V
FAU - Tiwari, Arun K
AU  - Tiwari AK
FAU - Squassina, Alessio
AU  - Squassina A
FAU - Zai, Gwyneth C
AU  - Zai GC
FAU - Shaikh, Sajid A
AU  - Shaikh SA
FAU - Strauss, John
AU  - Strauss J
FAU - King, Nicole
AU  - King N
FAU - Le Foll, Bernard
AU  - Le Foll B
FAU - Kaplan, Allan S
AU  - Kaplan AS
FAU - Finseth, Per I
AU  - Finseth PI
FAU - Vaaler, Arne E
AU  - Vaaler AE
FAU - Djurovic, Srdjan
AU  - Djurovic S
FAU - Andreassen, Ole A
AU  - Andreassen OA
FAU - Vincent, John B
AU  - Vincent JB
FAU - Kennedy, James L
AU  - Kennedy JL
LA  - eng
GR  - T32 MH076694/MH/NIMH NIH HHS/United States
GR  - T32MH076694/MH/NIMH NIH HHS/United States
GR  - CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140929
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DRD3 protein, human)
RN  - 0 (Receptors, Dopamine D3)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
EIN - World J Biol Psychiatry. 2020 Dec;21(10):798. PMID: 32697128
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Canada
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Dopamine D3/*genetics
MH  - Risk Factors
MH  - Schizophrenia/*genetics
MH  - Suicide, Attempted/*psychology
PMC - PMC4377309
MID - NIHMS655330
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - dopamine receptor DRD3
OT  - genetics
OT  - schizophrenia
OT  - suicide
COIS- STATEMENT OF INTERESTS JLK: honoraria from Roche, Novartis, and Lilly. CCZ: 
      honorium from WebMD for Medscape review. JLK & CCZ: patent application "Genetic 
      Markers Associated with Suicide Risk and Methods of Use Thereof" submitted. OAA: 
      received speaker's honoraria from GSK, Lilly, Otsuka, and Lundbeck. MM, IES, ZY, 
      VdL, AKT, AS, GCZ, SAS, JS, NK, BLF, ASK, PIF, AEV, SD, and JBV reported no 
      conflict of interest.
EDAT- 2014/09/30 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/04/01
CRDT- 2014/09/30 06:00
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.3109/15622975.2014.953011 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2015 Apr;16(3):171-9. doi: 10.3109/15622975.2014.953011. 
      Epub 2014 Sep 29.