PMID- 25264290
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20181202
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 16
IP  - 2
DP  - 2015 Feb
TI  - BDNF blood levels after non-invasive brain stimulation interventions in major 
      depressive disorder: a systematic review and meta-analysis.
PG  - 114-22
LID - 10.3109/15622975.2014.958101 [doi]
AB  - OBJECTIVES: To evaluate whether the antidepressant effects of novel non-invasive 
      brain stimulation (NIBS) therapies are associated with neurotrophic effects, 
      indexed by peripheral brain-derived neurotrophic factor (BDNF) levels. METHODS: 
      Systematic review and meta-analysis. We included trials published in 
      PubMed/Medline from the first date available to June 2014 measuring BDNF blood 
      levels before and after repetitive transcranial magnetic stimulation or 
      transcranial direct current stimulation in depression. RESULTS: Eight datasets (n 
      = 259) were included. These studies enrolled mostly treatment-resistant 
      depression patients, who received daily stimulation sessions on the left 
      dorsolateral prefrontal cortex. BDNF did not increase after NIBS (Hedges' g = 
      0.03, 95% CI = -0.21 to 0.27), even when examining each intervention separately. 
      Meta-regressions did not identify the influence of any clinical and demographic 
      predictors on the outcome. Finally, Begg's funnel plot did not suggest 
      publication bias and results were robust according to sensitivity analysis. 
      CONCLUSIONS: Peripheral BDNF levels do not increase after NIBS in depression. 
      Such biomarker might, therefore, not be suitable to index NIBS antidepressant 
      response. Further trials are needed, particularly exploring non-medicated 
      populations, performing subsequent BDNF assessments in a larger timeframe and 
      employing more intensive NIBS treatment protocols.
FAU - Brunoni, Andre R
AU  - Brunoni AR
AD  - Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, 
      University of Sao Paulo , Sao Paulo , Brazil.
FAU - Baeken, Chris
AU  - Baeken C
FAU - Machado-Vieira, Rodrigo
AU  - Machado-Vieira R
FAU - Gattaz, Wagner F
AU  - Gattaz WF
FAU - Vanderhasselt, Marie-Anne
AU  - Vanderhasselt MA
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140929
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*therapy
MH  - Depressive Disorder, Treatment-Resistant/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/physiology
MH  - *Transcranial Direct Current Stimulation
MH  - *Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - major depressive disorder
OT  - meta-analysis
OT  - neurotrophic factors
OT  - non-invasive brain stimulation
EDAT- 2014/09/30 06:00
MHDA- 2015/11/17 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - 10.3109/15622975.2014.958101 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2015 Feb;16(2):114-22. doi: 
      10.3109/15622975.2014.958101. Epub 2014 Sep 29.