PMID- 25264629
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20191210
IS  - 1555-9823 (Electronic)
IS  - 0003-1348 (Linking)
VI  - 80
IP  - 10
DP  - 2014 Oct
TI  - Mucinous cystic neoplasms of the pancreas: are we overestimating malignant 
      potential?
PG  - 915-9
AB  - Surgical resection is recommended for all mucinous cystic neoplasms (MCNs) of the 
      pancreas as a result of: 1) lack of an accurate tumor marker for invasive cancer; 
      2) young age at diagnosis; and 3) historical studies revealing 36 per cent 
      incidence of malignancy in resected lesions. This study compares the 
      clinicopathologic and prognostic features of our series of resected MCNs to 
      recent studies using the current International Association of Pancreatology (IAP) 
      system. Thirty-eight resected MCNs were identified. Almost all patients were 
      female (97.4%); median age at diagnosis was 53.5 years (interquartile range 
      [IQR], 41.3 to 61.0). The majority occurred in the body/tail of the pancreas 
      (86.8%); median size on computed tomography/magnetic resonance imaging was 5.0 cm 
      (IQR, 3 to 8.8). Comparison of the five high-grade (HG, 13.2%) and 33 low-grade 
      (86.8%) MCNs revealed that 1) patients were similar in age (55.0 vs 52.0 years, 
      respectively) and 2) HG lesions were significantly larger on preoperative imaging 
      (9.9 vs 3.5 cm) and final pathology (10.9 vs 3.5 cm). These data, taken together 
      with five recent studies that adhere to the 2012 IAP criteria (385 total MCNs), 
      reveal that a cutoff of less than 3 cm without mural nodules would have only 
      missed one (0.26%) HG lesion. Surveillance of these lesions may be appropriate 
      for some patients.
FAU - Nguyen, David
AU  - Nguyen D
AD  - UCLA Medical Center, Los Angeles, California, USA.
FAU - Dawson, David W
AU  - Dawson DW
FAU - Hines, O Joe
AU  - Hines OJ
FAU - Reber, Howard A
AU  - Reber HA
FAU - Donahue, Timothy R
AU  - Donahue TR
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
SB  - IM
MH  - Adult
MH  - Cystadenoma, Mucinous/diagnosis/*pathology/surgery
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Pancreatectomy
MH  - Pancreatic Neoplasms/diagnosis/*pathology/surgery
MH  - Preoperative Period
MH  - Prognosis
MH  - Tomography, X-Ray Computed
EDAT- 2014/09/30 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PST - ppublish
SO  - Am Surg. 2014 Oct;80(10):915-9.