PMID- 25264760
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 9
DP  - 2014
TI  - Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients 
      infected by Chikungunya or Dengue type-2 viruses.
PG  - e108798
LID - 10.1371/journal.pone.0108798 [doi]
LID - e108798
AB  - BACKGROUND: Natural killer (NK) cells provide defense in the early stages of the 
      immune response against viral infections. Killer cell immunoglobulin-like 
      receptors (KIR) expressed on the surface of NK cells play an important role in 
      regulating NK cell response through recognition of human leukocyte antigen (HLA) 
      class I molecules on target cells. Previous studies have shown that specific 
      KIR/ligand combinations are associated with the outcome of several viral 
      infectious diseases. METHODS: We investigated the impact of inhibitory and 
      activating KIR and their HLA-class I ligand genotype on the susceptibility to 
      Chikungunya virus (CHIKV) and Dengue virus (DENV2) infections. From April to July 
      2010 in Gabon, a large outbreak of CHIKV and DENV2 concomitantly occurred in two 
      provinces of Gabon (Ogooue-Lolo and Haut-Ogooue). We performed the genotypic 
      analysis of KIR in the combination with their cognate HLA-class I ligands in 73 
      CHIKV and 55 DENV2 adult cases, compared with 54 healthy individuals. RESULTS: We 
      found in CHIV-infected patients that KIR2DL1 and KIR2DS5 are significantly 
      increased and decreased respectively, as compared to DENV2+ patients and healthy 
      donors. The combination of KIR2DL1 and its cognate HLA-C2 ligand was 
      significantly associated with the susceptibility to CHIKV infection. In contrast, 
      no other inhibitory KIR-HLA pairs showed an association with the two 
      mosquito-borne arboviruses. CONCLUSION: These observations are strongly 
      suggestive that the NK cell repertoire shaped by the KIR2DL1:HLA-C2 interaction 
      facilitate specific infection by CHIKV.
FAU - Petitdemange, Caroline
AU  - Petitdemange C
AD  - Sorbonne Universites, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; 
      INSERM, U1135, CIMI-Paris, Paris, France; Centre International de Recherches 
      Medicales de Franceville, Unite des maladies Emergentes, Franceville, Gabon.
FAU - Wauquier, Nadia
AU  - Wauquier N
AD  - Sorbonne Universites, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; 
      Metabiota Inc., San Francisco, California, United States of America.
FAU - Jacquet, Jean-Michel
AU  - Jacquet JM
AD  - AP-HP Hopital Pitie-Salpetriere, Departement d'Immunologie, Paris, France.
FAU - Theodorou, Ioannis
AU  - Theodorou I
AD  - Sorbonne Universites, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; 
      INSERM, U1135, CIMI-Paris, Paris, France; AP-HP Hopital Pitie-Salpetriere, 
      Departement d'Immunologie, Paris, France.
FAU - Leroy, Eric
AU  - Leroy E
AD  - Centre International de Recherches Medicales de Franceville, Unite des maladies 
      Emergentes, Franceville, Gabon; IRD, Maladies Infectieuses et Vecteurs: Ecologie, 
      Genetique, Evolution et Controle, Montpellier, France.
FAU - Vieillard, Vincent
AU  - Vieillard V
AD  - Sorbonne Universites, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; 
      INSERM, U1135, CIMI-Paris, Paris, France; CNRS, ERL8255, CIMI-Paris, Paris, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140929
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chikungunya Fever/*immunology/virology
MH  - Chikungunya virus/*immunology
MH  - Dengue/genetics/*immunology/virology
MH  - Dengue Virus/*immunology
MH  - Female
MH  - Gabon
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Ligands
MH  - Male
MH  - Receptors, KIR/*genetics
PMC - PMC4181859
COIS- Competing Interests: Nadia Wauquier is consultant at Metabiota Inc. This does not 
      alter the authors' adherence to PLOS ONE policies on sharing data and materials. 
      The remaining authors declare no conflicts of interest. All authors have 
      contributed to, seen, and approved the final, revised version of the manuscript.
EDAT- 2014/09/30 06:00
MHDA- 2015/09/29 06:00
PMCR- 2014/09/29
CRDT- 2014/09/30 06:00
PHST- 2014/03/13 00:00 [received]
PHST- 2014/09/02 00:00 [accepted]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
PHST- 2014/09/29 00:00 [pmc-release]
AID - PONE-D-14-10802 [pii]
AID - 10.1371/journal.pone.0108798 [doi]
PST - epublish
SO  - PLoS One. 2014 Sep 29;9(9):e108798. doi: 10.1371/journal.pone.0108798. 
      eCollection 2014.