PMID- 25265006
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20181202
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 24
IP  - 4
DP  - 2015 Apr-May
TI  - A hierarchical cluster analysis of normal-tension glaucoma using spectral-domain 
      optical coherence tomography parameters.
PG  - 328-33
LID - 10.1097/IJG.0000000000000159 [doi]
AB  - PURPOSE: Normal-tension glaucoma (NTG) is a heterogenous disease, and there is 
      still controversy about subclassifications of this disorder. On the basis of 
      spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with 
      hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal 
      nerve fiber layer (RNFL) thicknesses. PATIENTS AND METHODS: A total of 200 eyes 
      of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to 
      measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous 
      subgroups based on these variables using a hierarchical cluster analysis, and 
      compared clusters to evaluate diverse NTG characteristics. RESULTS: Three 
      clusters were found after hierarchical cluster analysis. Cluster 1 (62 eyes) had 
      the thickest RNFL and widest rim area, and showed early glaucoma features. 
      Cluster 2 (60 eyes) was characterized by the largest cup/disc ratio and cup 
      volume, and showed advanced glaucomatous damage. Cluster 3 (78 eyes) had small 
      disc areas in SD-OCT and were comprised of patients with significantly younger 
      age, longer axial length, and greater myopia than the other 2 groups. 
      CONCLUSIONS: A hierarchical cluster analysis of SD-OCT scans divided NTG patients 
      into 3 groups based upon ONH parameters and RNFL thicknesses. It is anticipated 
      that the small disc area group comprised of younger and more myopic patients may 
      show unique features unlike the other 2 groups.
FAU - Bae, Hyoung Won
AU  - Bae HW
AD  - Departments of *Ophthalmology, Severance Hospital, Institute of Vision Research 
      daggerResearch Affairs, Biostatistics Collaboration Unit, Yonsei University College of 
      Medicine double daggerDepartments of Ophthalmology, Asan Medical Center, College of Medicine, 
      University of Ulsan, Seoul, Korea.
FAU - Ji, Yongwoo
AU  - Ji Y
FAU - Lee, Hye Sun
AU  - Lee HS
FAU - Lee, Naeun
AU  - Lee N
FAU - Hong, Samin
AU  - Hong S
FAU - Seong, Gong Je
AU  - Seong GJ
FAU - Sung, Kyung Rim
AU  - Sung KR
FAU - Kim, Chan Yun
AU  - Kim CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Cluster Analysis
MH  - Female
MH  - Humans
MH  - Intraocular Pressure
MH  - Low Tension Glaucoma/*classification/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*classification/diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/methods
EDAT- 2014/09/30 06:00
MHDA- 2015/06/10 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - 10.1097/IJG.0000000000000159 [doi]
PST - ppublish
SO  - J Glaucoma. 2015 Apr-May;24(4):328-33. doi: 10.1097/IJG.0000000000000159.