PMID- 25266815
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20220316
IS  - 1941-837X (Electronic)
IS  - 1369-6998 (Linking)
VI  - 18
IP  - 1
DP  - 2015 Jan
TI  - Utilities for treatment-related adverse events in type 2 diabetes.
PG  - 45-55
LID - 10.3111/13696998.2014.971158 [doi]
AB  - OBJECTIVES: The impact of Type 2 diabetes mellitus (T2DM) on health-related 
      quality-of-life (HRQoL) is complex due to the burden of disease, lifelong 
      treatment requirements, and comorbidities. This study aimed to capture UK 
      societal utility values for health states associated with T2DM and 
      treatment-related adverse events (AEs) to assess the burden of the disease and 
      common AEs. METHODS: Nine health state descriptions were developed (from a 
      literature review and patient and clinician qualitative input) depicting the 
      burden associated with T2DM and treatment-related AEs. These were mild/moderate 
      urinary tract infection (UTI); severe UTI; mycotic infection; moderate 
      hypoglycemic events; severe hypoglycemic events; fear of hypoglycemia; 
      gastrointestinal symptoms; and hypovolemic events. Members of the UK general 
      public (n = 100) valued these states using the time trade-off (TTO) methodology 
      to elicit utility values (between 0 = dead, 1 = full health). Regression analysis 
      was conducted to understand the influence of age and gender. RESULTS: All 
      treatment-related AEs were found to have a significant effect on utility. From 
      the T2DM baseline state (0.92), the experience of AEs was associated with the 
      following disutility: T2DM with hypovolemic events (0.08); T2DM with 
      mild/moderate UTIs (0.09); T2DM with moderate hypoglycemic events (0.11); T2DM 
      with severe hypoglycemic events (0.15); T2DM with fear of hypoglycemia (0.15); 
      T2DM with severe UTIs (0.19); T2DM with GI symptoms (0.24); and T2DM with mycotic 
      infection (0.25); Males consistently scored the states with significantly lower 
      utility values, but no significant age effects emerged. CONCLUSIONS: Findings 
      suggest that adverse events in T2DM can be a burden for some individuals. The 
      study indicates the potential importance of including information regarding AEs 
      in economic evaluations. Although some states were rated severely in terms of 
      utility; in reality, many of these only last a few days, therefore having a 
      minimal quality-adjusted life year (QALY) impact.
FAU - Shingler, S
AU  - Shingler S
AD  - ICON PRO , Oxford , UK.
FAU - Fordham, B
AU  - Fordham B
FAU - Evans, M
AU  - Evans M
FAU - Schroeder, M
AU  - Schroeder M
FAU - Thompson, G
AU  - Thompson G
FAU - Dewilde, S
AU  - Dewilde S
FAU - Lloyd, A J
AU  - Lloyd AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141010
PL  - England
TA  - J Med Econ
JT  - Journal of medical economics
JID - 9892255
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adult
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*complications/*drug therapy
MH  - Female
MH  - Gastrointestinal Diseases/chemically induced
MH  - Health Status
MH  - Humans
MH  - Hypoglycemia/chemically induced
MH  - Hypoglycemic Agents/*adverse effects/therapeutic use
MH  - Hypovolemia/chemically induced
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Mycoses/chemically induced
MH  - *Quality of Life
MH  - Socioeconomic Factors
MH  - United Kingdom
MH  - Urinary Tract Infections/chemically induced
OTO - NOTNLM
OT  - Co-morbidities
OT  - Quality-of-life
OT  - Type 2 diabetes
OT  - Utility
EDAT- 2014/10/01 06:00
MHDA- 2015/09/16 06:00
CRDT- 2014/10/01 06:00
PHST- 2014/10/01 06:00 [entrez]
PHST- 2014/10/01 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - 10.3111/13696998.2014.971158 [doi]
PST - ppublish
SO  - J Med Econ. 2015 Jan;18(1):45-55. doi: 10.3111/13696998.2014.971158. Epub 2014 
      Oct 10.