PMID- 25266830
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20221207
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Linking)
VI  - 18
IP  - 5
DP  - 2014 Oct
TI  - Incidence of fovea plana in normal children.
PG  - 471-5
LID - S1091-8531(14)00421-2 [pii]
LID - 10.1016/j.jaapos.2014.07.157 [doi]
AB  - PURPOSE: To characterize the prevalence and features of subclinical foveal 
      hypoplasia detected by optical coherence tomography (OCT) in children. METHODS: 
      Fast macular OCT scans were performed on normal children with normal vision for 
      the development of a normative OCT-3 database; from this data, eyes with no 
      discernable foveal depression were identified. When possible, the ocular imaging 
      was repeated 3 years later using both OCT-3 and spectral domain OCT (SD-OCT). 
      SD-OCT results were compared to age-matched controls. RESULTS: Of the 286 normal 
      children (mean age, 8.6 +/- 3.1 years) scanned, 9 (mean age, 8 +/- 2.9 years; 6 
      males) were found to have bilateral shallow foveal depression on OCT-3 imaging, 
      including 8 of 154 white children (5.4%) and 1 child of mixed ethnicity 
      (white/black). Children with shallow foveas (n = 9) had larger average foveal 
      thickness (FT) compared to the cohort of controls (n = 277) with a defined fovea 
      (FT = 231.4 +/- 8.8 vs 188.8 +/- 25.0, resp. [P < 0.0001]). Mean macular volume did 
      not differ from that of controls. SD-OCT performed 3 years later on 5 of the 9 
      children with shallow foveal depression showed persistence of the inner macular 
      layers over the foveal center, corresponding to grades 1 or 2 of foveal 
      hypoplasia. The FT was increased compared to 5 age-matched controls with a 
      defined fovea (FT = 294.5 +/- 5.1 vs 219.75 +/- 5.68 mum, resp. [P = 0.029]). 
      CONCLUSIONS: Up to 3% of children with clinically normal eyes had an anatomically 
      underdeveloped foveal pit bilaterally on OCT.
CI  - Copyright (c) 2014 American Association for Pediatric Ophthalmology and Strabismus. 
      Published by Elsevier Inc. All rights reserved.
FAU - Noval, Susana
AU  - Noval S
AD  - Duke Eye Center, Durham, North Carolina; Department of Ophthalmology, La Paz 
      University Hospital, IdiPaz, Madrid.
FAU - Freedman, Sharon F
AU  - Freedman SF
AD  - Duke Eye Center, Durham, North Carolina.
FAU - Asrani, Sanjay
AU  - Asrani S
AD  - Duke Eye Center, Durham, North Carolina.
FAU - El-Dairi, Mays A
AU  - El-Dairi MA
AD  - Duke Eye Center, Durham, North Carolina. Electronic address: 
      mays.el-dairi@dm.duke.edu.
LA  - eng
PT  - Journal Article
DEP - 20140927
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
RN  - Foveal Hypoplasia, Isolated
SB  - IM
MH  - Black or African American
MH  - Child
MH  - Child, Preschool
MH  - Eye Diseases, Hereditary/*diagnosis/*epidemiology/ethnology/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/*abnormalities/physiopathology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - North Carolina/epidemiology
MH  - Nystagmus, Congenital/*diagnosis/*epidemiology/ethnology/physiopathology
MH  - Prevalence
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - White People
EDAT- 2014/10/01 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/10/01 06:00
PHST- 2013/08/03 00:00 [received]
PHST- 2014/06/30 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/10/01 06:00 [entrez]
PHST- 2014/10/01 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - S1091-8531(14)00421-2 [pii]
AID - 10.1016/j.jaapos.2014.07.157 [doi]
PST - ppublish
SO  - J AAPOS. 2014 Oct;18(5):471-5. doi: 10.1016/j.jaapos.2014.07.157. Epub 2014 Sep 
      27.