PMID- 25266958
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20151112
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 28
IP  - 14
DP  - 2015
TI  - Placental gene expression of transforming growth factor beta 1 (TGF-beta1) in small 
      for gestational age newborns.
PG  - 1701-5
AB  - OBJECTIVE: The gene expression of transforming growth factor beta-1 (TGF-beta1) in 
      human placental samples obtained from pregnancies with small for gestational age 
      fetuses (SGA) was compared to those of normal pregnancies. METHODS: In 2011 
      placental samples from 101 pregnancies with SGA and from 140 normal pregnancies 
      were obtained for analysis of TGF-beta1 gene expression. Several clinical parameters 
      were also assessed for correlation between genetic and clinical parameters. 
      RESULTS: There were no significant differences in gene activity of the TGF-beta1 
      gene between the SGA versus normal pregnancy groups (Ln2alpha: 0.16; p = 0.07). 
      Within the SGA group, no fetal gender-dependent differences were seen in TGF-beta1 
      gene expression (Ln2alpha: -0.11; p = 0.05). Similarly, no significant differences in 
      gene activity were observed by the degree of severity of SGA as assessed by 
      percentile fetal birth-weight (Ln2alpha: 0.32; p = 0.06). CONCLUSION: We found no 
      change in gene expression of TGF-beta1 in placental samples obtained from SGA 
      pregnancies versus normal pregnancy suggesting an absence of a direct role of the 
      TGF-beta1 gene in the development of SGA. However, the absence of increased gene 
      expression of TGF-beta1 in SGA can be conceptualized as a failure to mount a 
      compensatory response in the SGA environment.
FAU - Rab, Attila
AU  - Rab A
FAU - Szentpeterib, Imre
AU  - Szentpeterib I
FAU - Kornyac, Laszlo
AU  - Kornyac L
FAU - Borzsonyid, Balazs
AU  - Borzsonyid B
FAU - Demendid, Csaba
AU  - Demendid C
FAU - Valent, Sandor
AU  - Valent S
FAU - Zsom, Lajos
AU  - Zsom L
FAU - Hejja, Hajnalka
AU  - Hejja H
FAU - Joof, Jozsef Gabor
AU  - Joof JG
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Biomarkers)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Growth Retardation/*genetics/metabolism
MH  - *Gene Expression
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Small for Gestational Age
MH  - Male
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transforming Growth Factor beta1/*genetics/metabolism
EDAT- 2014/10/01 06:00
MHDA- 2016/06/10 06:00
CRDT- 2014/10/01 06:00
PHST- 2014/10/01 06:00 [entrez]
PHST- 2014/10/01 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.3109/14767058.2014.966673 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2015;28(14):1701-5. doi: 
      10.3109/14767058.2014.966673.