PMID- 25267345
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20181202
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 12
IP  - 3
DP  - 2015 Mar
TI  - Advances in oral controlled drug delivery: the role of drug-polymer and 
      interpolymer non-covalent interactions.
PG  - 441-53
LID - 10.1517/17425247.2015.966685 [doi]
AB  - INTRODUCTION: After more than four decades of intense research, oral controlled 
      drug delivery systems (DDSs) still represent a topic of major interest for 
      pharmaceutical scientist and formulators. This can be explained in part by 
      considering the economic value of oral DDSs whose market accounts for more than 
      half of the overall drug delivery market. Polymeric systems based on drug-polymer 
      non-covalent interaction represent a limited, but growing part of the field. 
      Despite the large amount of literature and published reviews covering specific 
      aspects, there is still need for a review of the relevant literature providing a 
      general picture of the topic. AREAS COVERED: The present review aims at 
      presenting the latest findings in drug-polymer and interpolymer non-covalent 
      interactions in oral controlled delivery while providing a specific perspective 
      and a critical point of view, particularly on the tools and methods used for the 
      study of these DDSs. Four main sections are considered: i) ionic interactions 
      between drugs and polymers; ii) interpolymer complexes; iii) hydrogen bond; and 
      iv) hydrophobic interactions. EXPERT OPINION: The largest part of the scientific 
      literature deals with systems based on drug-polymer ionic interactions while 
      hydrogen bonding and hydrophobic interaction though, very promising, are more 
      difficult to exploit, and therefore less studied. An accurate and exhaustive 
      representation of the specific role of the chemical functions in establishing 
      predictable interactions between drug and polymers is still required.
FAU - De Robertis, Simona
AU  - De Robertis S
AD  - PhD Student, University of Parma, Department of Pharmacy , Parma , Italy.
FAU - Bonferoni, Maria Cristina
AU  - Bonferoni MC
FAU - Elviri, Lisa
AU  - Elviri L
FAU - Sandri, Giuseppina
AU  - Sandri G
FAU - Caramella, Carla
AU  - Caramella C
FAU - Bettini, Ruggero
AU  - Bettini R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140930
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Excipients)
RN  - 0 (Ions)
RN  - 0 (Polymers)
SB  - IM
MH  - Administration, Oral
MH  - Chemistry, Pharmaceutical/*methods
MH  - Delayed-Action Preparations/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Drug Liberation
MH  - Excipients/*chemistry
MH  - Hydrogen Bonding
MH  - Ions/chemistry
MH  - Polymers/*chemistry
OTO - NOTNLM
OT  - Eudragit
OT  - alginate
OT  - carrageenan
OT  - chitosan
OT  - controlled release
OT  - drug-polymer interaction
OT  - interpolymer complex
OT  - oral delivery
OT  - polyelectrolyte complex
EDAT- 2014/10/01 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/10/01 06:00
PHST- 2014/10/01 06:00 [entrez]
PHST- 2014/10/01 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1517/17425247.2015.966685 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2015 Mar;12(3):441-53. doi: 10.1517/17425247.2015.966685. 
      Epub 2014 Sep 30.