PMID- 25268438
OWN - NLM
STAT- MEDLINE
DCOM- 20141002
LR  - 20240222
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 312
IP  - 13
DP  - 2014 Oct 1
TI  - Acupuncture for chronic knee pain: a randomized clinical trial.
PG  - 1313-22
LID - 10.1001/jama.2014.12660 [doi]
AB  - IMPORTANCE: There is debate about benefits of acupuncture for knee pain. 
      OBJECTIVE: To determine the efficacy of laser and needle acupuncture for chronic 
      knee pain. DESIGN, SETTING, AND PARTICIPANTS: Zelen-design clinical trial 
      (randomization occurred before informed consent), in Victoria, Australia 
      (February 2010-December 2012). Community volunteers (282 patients aged >/=50 years 
      with chronic knee pain) were treated by family physician acupuncturists. 
      INTERVENTIONS: No acupuncture (control group, n = 71) and needle (n = 70), laser 
      (n = 71), and sham laser (n = 70) acupuncture. Treatments were delivered for 12 
      weeks. Participants and acupuncturists were blinded to laser and sham laser 
      acupuncture. Control participants were unaware of the trial. MAIN OUTCOMES AND 
      MEASURES: Primary outcomes were average knee pain (numeric rating scale, 0 [no 
      pain] to 10 [worst pain possible]; minimal clinically important difference 
      [MCID], 1.8 units) and physical function (Western Ontario and McMaster 
      Universities Osteoarthritis Index, 0 [no difficulty] to 68 [extreme difficulty]; 
      MCID, 6 units) at 12 weeks. Secondary outcomes included other pain and function 
      measures, quality of life, global change, and 1-year follow-up. Analyses were by 
      intention-to-treat using multiple imputation for missing outcome data. RESULTS: 
      At 12 weeks and 1 year, 26 (9%) and 50 (18%) participants were lost to follow-up, 
      respectively. Analyses showed neither needle nor laser acupuncture significantly 
      improved pain (mean difference; -0.4 units; 95% CI, -1.2 to 0.4, and -0.1; 95% 
      CI, -0.9 to 0.7, respectively) or function (-1.7; 95% CI, -6.1 to 2.6, and 0.5; 
      95% CI, -3.4 to 4.4, respectively) compared with sham at 12 weeks. Compared with 
      control, needle and laser acupuncture resulted in modest improvements in pain 
      (-1.1; 95% CI, -1.8 to -0.4, and -0.8; 95% CI, -1.5 to -0.1, respectively) at 12 
      weeks, but not at 1 year. Needle acupuncture resulted in modest improvement in 
      function compared with control at 12 weeks (-3.9; 95% CI, -7.7 to -0.2) but was 
      not significantly different from sham (-1.7; 95% CI, -6.1 to 2.6) and was not 
      maintained at 1 year. There were no differences for most secondary outcomes and 
      no serious adverse events. CONCLUSIONS AND RELEVANCE: In patients older than 50 
      years with moderate or severe chronic knee pain, neither laser nor needle 
      acupuncture conferred benefit over sham for pain or function. Our findings do not 
      support acupuncture for these patients. TRIAL REGISTRATION: anzctr.org.au 
      Identifier: ACTRN12609001001280.
FAU - Hinman, Rana S
AU  - Hinman RS
AD  - Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, 
      School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, 
      University of Melbourne, Melbourne, Australia.
FAU - McCrory, Paul
AU  - McCrory P
AD  - Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, 
      School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, 
      University of Melbourne, Melbourne, Australia2Florey Institute of Neuroscience 
      and Mental Health.
FAU - Pirotta, Marie
AU  - Pirotta M
AD  - Department of General Practice, School of Medicine, Faculty of Medicine, 
      Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
FAU - Relf, Ian
AU  - Relf I
AD  - Department of General Practice, School of Medicine, Faculty of Medicine, 
      Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
FAU - Forbes, Andrew
AU  - Forbes A
AD  - Epidemiology and Preventative Medicine, Faculty of Medicine, Nursing and Health 
      Sciences, Monash University, Melbourne, Australia.
FAU - Crossley, Kay M
AU  - Crossley KM
AD  - Division of Physiotherapy, School of Health and Rehabilitation Sciences, 
      University of Queensland, Brisbane, Australia.
FAU - Williamson, Elizabeth
AU  - Williamson E
AD  - Farr Institute of Health Informatics Research, London, United Kingdom7Department 
      of Medical Statistics, London School of Hygiene and Tropical Medicine, London, 
      United Kingdom.
FAU - Kyriakides, Mary
AU  - Kyriakides M
AD  - Department of General Practice, School of Medicine, Faculty of Medicine, 
      Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
FAU - Novy, Kitty
AU  - Novy K
AD  - Department of General Practice, School of Medicine, Faculty of Medicine, 
      Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
FAU - Metcalf, Ben R
AU  - Metcalf BR
AD  - Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, 
      School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, 
      University of Melbourne, Melbourne, Australia.
FAU - Harris, Anthony
AU  - Harris A
AD  - Centre for Health Economics, Faculty of Business and Economics, Monash 
      University, Melbourne, Australia.
FAU - Reddy, Prasuna
AU  - Reddy P
AD  - School of Medicine and Public Health, Faculty of Health and Medicine, University 
      of Newcastle, Callaghan, Newcastle, Australia.
FAU - Conaghan, Philip G
AU  - Conaghan PG
AD  - Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds 
      and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom.
FAU - Bennell, Kim L
AU  - Bennell KL
AD  - Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, 
      School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, 
      University of Melbourne, Melbourne, Australia.
LA  - eng
SI  - ANZCTR/ACTRN12609001001280
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
RN  - 0 (Analgesics)
SB  - IM
CIN - JAMA. 2014 Oct 1;312(13):1342-3. PMID: 25268441
SPIN- JAMA. 2014 Oct 1;312(13):1365. PMID: 25268455
CIN - BMJ. 2014;349:g5899. PMID: 25273362
CIN - Acupunct Med. 2015 Feb;33(1):84-6. PMID: 25538292
CIN - Praxis (Bern 1994). 2015 Jan 2;104(1):51-2. PMID: 25552449
CIN - Acupunct Med. 2015 Feb;33(1):86-8. PMID: 25595194
CIN - JAMA. 2015 Feb 10;313(6):626-7. PMID: 25668269
CIN - JAMA. 2015 Feb 10;313(6):626. PMID: 25668270
CIN - JAMA. 2015 Feb 10;313(6):627. PMID: 25668271
CIN - JAMA. 2015 Feb 10;313(6):627-8. PMID: 25668272
CIN - JAMA. 2015 Feb 10;313(6):628. PMID: 25668273
CIN - JAMA. 2015 Feb 10;313(6):628-9. PMID: 25668274
CIN - Acupunct Med. 2015 Apr;33(2):170. PMID: 25742694
CIN - J Integr Med. 2015 Mar;13(2):65-8. PMID: 25797635
CIN - J Integr Med. 2015 May;13(3):136-9. PMID: 26006026
CIN - Zhongguo Zhen Jiu. 2015 Mar;35(3):299-304. PMID: 26062211
CIN - J Integr Med. 2015 Jul;13(4):209-11. PMID: 26165363
CIN - Acupunct Med. 2015 Dec;33(6):499. PMID: 26185278
MH  - *Acupuncture Therapy/adverse effects/methods
MH  - Aged
MH  - Analgesics/therapeutic use
MH  - Chronic Pain/drug therapy/*therapy
MH  - Female
MH  - Humans
MH  - Knee
MH  - *Low-Level Light Therapy/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2014/10/01 06:00
MHDA- 2014/10/03 06:00
CRDT- 2014/10/01 06:00
PHST- 2014/10/01 06:00 [entrez]
PHST- 2014/10/01 06:00 [pubmed]
PHST- 2014/10/03 06:00 [medline]
AID - 1910110 [pii]
AID - 10.1001/jama.2014.12660 [doi]
PST - ppublish
SO  - JAMA. 2014 Oct 1;312(13):1313-22. doi: 10.1001/jama.2014.12660.