PMID- 25270202
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20141001
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 30
IP  - 10
DP  - 2014 Oct
TI  - [Dachengqi decoction reduces the serum levels of mast cell tryptase and 
      inflammatory cytokines in rabbits with post-cardiac arrest syndrome].
PG  - 1026-9
AB  - OBJECTIVE: To observe the effects of Dachengqi decoction on serum levels of mast 
      cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 
      (IL-8) in rabbits with post-cardiac arrest syndrome (PCAS). METHODS: Thirty 
      healthy male Japanese rabbits were randomly divided into three groups: 
      sham-operation group, PCAS model group and Dachengqi decoction treatment group. 
      The model of PCAS was established by asphyxia-induced cardiac arrest. Fifteen 
      minutes after return of spontaneous circulation, Dachengqi decoction [15 
      g/(kg.d), bid] was given by intra-gastric administration in Dachengqi decoction 
      treatment group. The indicators of organ function were evaluated 24, 48 and 72 
      hours after cardiac arrest. The serum levels of mast cell tryptase, MCP-1 and 
      IL-8 were determined by ELISA. RESULTS: Dachengqi decoction alleviated the 
      dysfunction significantly in heart, brain, liver and kidney. Compared with the 
      sham group, the serum levels of mast cell tryptase, MCP-1 and IL-8 increased 
      significantly in PCAS group (P<0.01). Compared with the PCAS group, the serum 
      levels of mast cell tryptase (at 6 hours), MCP-1 (at 6, 24 and 48 hours) and IL-8 
      (at 6 and 24 hours) decreased significantly in Dachengqi decoction treatment 
      group (P<0.05 or P<0.01). CONCLUSION: Dachengqi decoction can reduce the serum 
      levels of mast cell tryptase, MCP-1 and IL-8 in rabbits with post-cardiac arrest 
      syndrome.
FAU - Yang, Jingning
AU  - Yang J
AD  - Department of Emergency Medicine, Taihe Hospital, Department of Immunology, Hubei 
      Medical University, Shiyan 442000, China.
FAU - Xiao, Min
AU  - Xiao M
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
FAU - Wang, Xuejun
AU  - Wang X
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
FAU - Liang, Pengfei
AU  - Liang P
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
FAU - Chai, Lin
AU  - Chai L
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
FAU - Luo, Ming
AU  - Luo M
AD  - Department of Emergency Medicine, Taihe Hospital, Shiyan 442000, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Plant Extracts)
RN  - 0 (dachengqi decoction)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Heart Arrest/blood/physiopathology/*prevention & control
MH  - Interleukin-8/*blood
MH  - Male
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - Rabbits
MH  - Random Allocation
MH  - Syndrome
MH  - Treatment Outcome
MH  - Tryptases/*blood
EDAT- 2014/10/02 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/10/02 06:00
PHST- 2014/10/02 06:00 [entrez]
PHST- 2014/10/02 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Oct;30(10):1026-9.