PMID- 25270590
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20231110
IS  - 2047-2927 (Electronic)
IS  - 2047-2919 (Print)
IS  - 2047-2919 (Linking)
VI  - 2
IP  - 6
DP  - 2014 Nov
TI  - Association of serum inorganic phosphate with sex steroid hormones and vitamin D 
      in a nationally representative sample of men.
PG  - 967-76
LID - 10.1111/andr.285 [doi]
AB  - Defects in bone regulatory pathways have been linked to chronic diseases 
      including cardiovascular disease and cancer. In men, a link between bone 
      metabolism and gonadal hormones has been suggested. However, to date, there is 
      lack of evidence on the association between serum inorganic phosphate (Pi) and 
      sex steroid hormones. The objective of this study was to investigate the 
      association between Pi, sex steroid hormones and a known Pi metabolic regulator, 
      vitamin D, in men in the National Health and Nutrition Examination Survey III 
      (NHANES III). From NHANES III, we selected 1412 men aged 20+ who participated in 
      the morning session of Phase I (1988-1991) with serum measurements of Pi, sex 
      hormones, and vitamin D. Multivariable linear regression was used to calculate 
      crude and geometric mean Pi by total and estimated free testosterone and 
      estradiol, sex hormone-binding globulin, androstanediol glucuronide (AAG), and 
      vitamin D. Similar analyses were performed while stratifying by race/ethnicity 
      and vitamin D levels. We found a lack of statistically significant difference in 
      geometric means of Pi across quintiles of concentrations of sex hormones, 
      indicating a tight regulation of Pi. However, Pi levels were inversely associated 
      with calculated free testosterone in non-Hispanic black men, with geometric mean 
      levels of Pi of 1.16 and 1.02 ng/mL for those in the lowest and highest quintiles 
      of free testosterone, respectively (p-trend < 0.05). A similar but weaker pattern 
      was seen between total testosterone and Pi. An inverse association was also seen 
      between AAG and Pi in men with vitamin D concentration below the median 
      (<24.2 ng/mL). No associations were observed among men with vitamin D levels at 
      or above the median. Our findings suggest a weak link among sex hormones, vitamin 
      D, and Pi in men. The observed effects of race/ethnicity and vitamin D indicate a 
      complex association involving various regulators of Pi homeostasis.
CI  - (c) 2014 American Society of Andrology and European Academy of Andrology.
FAU - Wulaningsih, W
AU  - Wulaningsih W
AD  - Cancer Epidemiology Unit, Division of Cancer Studies, King's College London, 
      School of Medicine, London, UK.
FAU - Van Hemelrijck, M
AU  - Van Hemelrijck M
FAU - Michaelsson, K
AU  - Michaelsson K
FAU - Kanarek, N
AU  - Kanarek N
FAU - Nelson, W G
AU  - Nelson WG
FAU - Ix, J H
AU  - Ix JH
FAU - Platz, E A
AU  - Platz EA
FAU - Rohrmann, S
AU  - Rohrmann S
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141001
PL  - England
TA  - Andrology
JT  - Andrology
JID - 101585129
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Phosphates)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Gonadal Steroid Hormones/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Phosphates/*blood
MH  - Switzerland
MH  - Vitamin D/*blood
PMC - PMC4324600
MID - NIHMS660078
OTO - NOTNLM
OT  - cross-sectional studies
OT  - gonadal steroid hormones
OT  - serum inorganic phosphate
COIS- CONFLICT OF INTERESTS None declared.
EDAT- 2014/10/02 06:00
MHDA- 2015/06/24 06:00
PMCR- 2015/02/11
CRDT- 2014/10/02 06:00
PHST- 2014/04/24 00:00 [received]
PHST- 2014/08/31 00:00 [revised]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/10/02 06:00 [entrez]
PHST- 2014/10/02 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PHST- 2015/02/11 00:00 [pmc-release]
AID - 10.1111/andr.285 [doi]
PST - ppublish
SO  - Andrology. 2014 Nov;2(6):967-76. doi: 10.1111/andr.285. Epub 2014 Oct 1.