PMID- 25271077
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20181202
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 476
IP  - 1-2
DP  - 2014 Dec 10
TI  - A mesoporous silicon/poly-(DL-lactic-co-glycolic) acid microsphere for long time 
      anti-tuberculosis drug delivery.
PG  - 116-23
LID - S0378-5173(14)00695-4 [pii]
LID - 10.1016/j.ijpharm.2014.09.040 [doi]
AB  - In this study, drug delivery systems for controlling release of hydrophobic 
      anti-tuberculosis (TB) drug-rifampicin (RIF) or hydrophilic anti-TB 
      drug-isoniazid (INH) from mesoporous silica (MS) were fabricated. The drug was 
      first filled into the mesopores of MS particles, and then the drug-laden MS 
      constructs were incorporated into the bulk of poly-(DL-lactic-co-glycolic) acid 
      (PLGA) microspheres. In comparison with mono-component construct (drug-laden MS 
      and drug-laden PLGA), this multi-component system significantly improved the 
      release time of RIF and INH. For drug-laden MS, about 100% INH was released after 
      15 h, and about 70% RIF was released after 50 h. For drug-laden PLGA, about 100% 
      INH and RIF were released after 30 and 40 days, respectively. After 60 days, the 
      total RIF and INH release from MS/PLGA had only reached around only 48% and 57%, 
      respectively. This MS/PLGA system could significantly prolong RIF or INH release 
      compared to MS and PLGA. CCK-8 assay demonstrated that this MS/PLGA system had no 
      cytotoxicity. And there has not been study of documenting the controlled release 
      of anti-TB drugs such as RIF or INH from MS/PLGA. Considering the long time 
      release of RIF and INH from MS/PLGA, a new door to bone TB would be opened.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Xu, Weikang
AU  - Xu W
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China; National Engineering Research Center for 
      Tissue Restoration and Reconstruction, Guangzhou 510006, China; Guangdong 
      Province Key Laboratory of Biomedical Engineering, South China University of 
      Technology, Guangzhou 510006, China.
FAU - Wei, Xinmiao
AU  - Wei X
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China; National Engineering Research Center for 
      Tissue Restoration and Reconstruction, Guangzhou 510006, China; Guangdong 
      Province Key Laboratory of Biomedical Engineering, South China University of 
      Technology, Guangzhou 510006, China.
FAU - Wei, Kun
AU  - Wei K
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China; National Engineering Research Center for 
      Tissue Restoration and Reconstruction, Guangzhou 510006, China; Guangdong 
      Province Key Laboratory of Biomedical Engineering, South China University of 
      Technology, Guangzhou 510006, China. Electronic address: weikun@scut.edu.cn.
FAU - Cao, Xiaodong
AU  - Cao X
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China; National Engineering Research Center for 
      Tissue Restoration and Reconstruction, Guangzhou 510006, China; Guangdong 
      Province Key Laboratory of Biomedical Engineering, South China University of 
      Technology, Guangzhou 510006, China.
FAU - Zhong, Shizhen
AU  - Zhong S
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou 510641, China; National Engineering Research Center for 
      Tissue Restoration and Reconstruction, Guangzhou 510006, China; Guangdong 
      Province Key Laboratory of Biomedical Engineering, South China University of 
      Technology, Guangzhou 510006, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140928
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Antitubercular Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - V83O1VOZ8L (Isoniazid)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
MH  - Antitubercular Agents/*administration & dosage/chemistry
MH  - Chemistry, Pharmaceutical/methods
MH  - Delayed-Action Preparations
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Isoniazid/*administration & dosage/chemistry
MH  - Lactic Acid/chemistry
MH  - Microspheres
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rifampin/*administration & dosage/chemistry
MH  - Silicon Dioxide/chemistry
MH  - Time Factors
OTO - NOTNLM
OT  - Isoniazid
OT  - Mesoporous silica
OT  - PLGA
OT  - Prolong release
OT  - Rifampicin
EDAT- 2014/10/02 06:00
MHDA- 2015/10/21 06:00
CRDT- 2014/10/02 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/09/15 00:00 [revised]
PHST- 2014/09/26 00:00 [accepted]
PHST- 2014/10/02 06:00 [entrez]
PHST- 2014/10/02 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - S0378-5173(14)00695-4 [pii]
AID - 10.1016/j.ijpharm.2014.09.040 [doi]
PST - ppublish
SO  - Int J Pharm. 2014 Dec 10;476(1-2):116-23. doi: 10.1016/j.ijpharm.2014.09.040. 
      Epub 2014 Sep 28.