PMID- 25271421
OWN - NLM
STAT- MEDLINE
DCOM- 20150610
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Meloxicam blocks neuroinflammation, but not depressive-like behaviors, in HIV-1 
      transgenic female rats.
PG  - e108399
LID - 10.1371/journal.pone.0108399 [doi]
LID - e108399
AB  - Adolescents living with human immunodeficiency virus (HIV) comprise approximately 
      12% of the HIV-positive population worldwide. HIV-positive adolescents experience 
      a higher rate of clinical depression, a greater risk of sexual and drug abuse 
      behaviors, and a decreased adherence to highly active antiretroviral therapies 
      (HAART). Using adolescent HIV-1 transgenic rats (HIV-1 tg) that display related 
      immune response alterations and pathologies, this study tested the hypothesis 
      that developmental expression of HIV-1-related proteins induces a depressive-like 
      phenotype that parallels a decrease in hippocampal cell proliferation and an 
      increase in pro-inflammatory cytokine expression in the hippocampus. Consistent 
      with this hypothesis, adolescent HIV-1 tg rats demonstrated a depressive-like 
      behavioral phenotype, had decreased levels of cell proliferation, and exhibited 
      elevated expression of monocyte chemotactic protein-1 (Mcp-1) in the hippocampus 
      relative to controls. Subsequently, we tested the ability of meloxicam, a 
      selective COX-2 inhibitor, to attenuate behavioral deficits via inflammatory 
      mechanisms. Daily meloxicam treatments did not alter the behavioral profile 
      despite effectively reducing hippocampal inflammatory gene expression. Together, 
      these data support a biological basis for the co-morbid manifestation of 
      depression in HIV-positive patients as early as in adolescence and suggest that 
      modifications in behavior manifest independent of inflammatory activity in the 
      hippocampus.
FAU - Nemeth, Christina L
AU  - Nemeth CL
AD  - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, 
      Georgia, United States of America; Department of Physiology, Emory University, 
      Atlanta, Georgia, United States of America.
FAU - Glasper, Erica R
AU  - Glasper ER
AD  - Department of Psychology, University of Maryland, College Park, Maryland, United 
      States of America.
FAU - Harrell, Constance S
AU  - Harrell CS
AD  - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, 
      Georgia, United States of America; Department of Physiology, Emory University, 
      Atlanta, Georgia, United States of America.
FAU - Malviya, Sanjana A
AU  - Malviya SA
AD  - Department of Physiology, Emory University, Atlanta, Georgia, United States of 
      America.
FAU - Otis, Jeffrey S
AU  - Otis JS
AD  - Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, 
      Atlanta, Georgia, United States of America.
FAU - Neigh, Gretchen N
AU  - Neigh GN
AD  - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, 
      Georgia, United States of America; Department of Physiology, Emory University, 
      Atlanta, Georgia, United States of America; Center for Behavioral Neuroscience, 
      Emory University, Atlanta, Georgia, United States of America.
LA  - eng
GR  - P30 AI027767/AI/NIAID NIH HHS/United States
GR  - T32 GM008169/GM/NIGMS NIH HHS/United States
GR  - T32 GM008605/GM/NIGMS NIH HHS/United States
GR  - P30 AI027767-24/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141001
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Anxiety
MH  - Behavior, Animal/*drug effects
MH  - Chemokine CCL2/genetics/metabolism
MH  - Depression
MH  - Female
MH  - Gene Expression
MH  - HIV Infections
MH  - HIV-1/*genetics
MH  - Hippocampus/*drug effects/metabolism/*pathology
MH  - Humans
MH  - *Inflammation/drug therapy
MH  - Meloxicam
MH  - Rats
MH  - Rats, Transgenic
MH  - Thiazines/administration & dosage/*pharmacology
MH  - Thiazoles/administration & dosage/*pharmacology
PMC - PMC4182732
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/02 06:00
MHDA- 2015/06/11 06:00
PMCR- 2014/10/01
CRDT- 2014/10/02 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/08/22 00:00 [accepted]
PHST- 2014/10/02 06:00 [entrez]
PHST- 2014/10/02 06:00 [pubmed]
PHST- 2015/06/11 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - PONE-D-14-25744 [pii]
AID - 10.1371/journal.pone.0108399 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 1;9(10):e108399. doi: 10.1371/journal.pone.0108399. 
      eCollection 2014.