PMID- 25272033
OWN - NLM
STAT- MEDLINE
DCOM- 20160101
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Spontaneous brain activity in type 2 diabetics revealed by amplitude of 
      low-frequency fluctuations and its association with diabetic vascular disease: a 
      resting-state FMRI study.
PG  - e108883
LID - 10.1371/journal.pone.0108883 [doi]
LID - e108883
AB  - PURPOSE: To investigate correlations between altered spontaneous brain activity, 
      diabetic vascular disease, and cognitive function for patients with type 2 
      diabetes mellitus (T2DM) using resting-state functional magnetic resonance 
      imaging (rs-fMRI). METHODS: Rs-fMRI was performed for T2DM patients (n = 26) and 
      age-, gender-, and education-matched non-diabetic control subjects (n = 26). 
      Amplitude of low frequency fluctuations (ALFF) were computed from fMRI signals to 
      measure spontaneous neuronal activity. Differences in the ALFF patterns between 
      patients and controls, as well as their correlations with clinical variables, 
      were evaluated. RESULTS: Compared with healthy controls, T2DM patients exhibited 
      significantly decreased ALFF values mainly in the frontal and parietal lobes, the 
      bilateral thalumi, the posterior lobe of the cerebellum, and increased ALFF 
      values mainly in the visual cortices. Furthermore, lower ALFF values in the left 
      subcallosal gyrus correlated with lower ankle-brachial index values (r = 0.481, p 
      = 0.020), while lower ALFF values in the bilateral medial prefrontal gyri 
      correlated with higher urinary albumin-creatinine ratio (r =  -0.418, p = 0.047). 
      In addition, most of the regions with increased ALFF values in the visual 
      cortices were found to negatively correlate with MoCA scores. CONCLUSIONS: These 
      results confirm that ALFF are altered in many brain regions in T2DM patients, and 
      this is associated with the presence of diabetic vascular disease and poor 
      cognitive performance. These findings may provide additional insight into the 
      neurophysiological mechanisms that mediate T2DM-related cognitive dysfunction, 
      and may also serve as a reference for future research.
FAU - Wang, Chun-Xia
AU  - Wang CX
AD  - Department of Medical Imaging, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, China.
FAU - Fu, Kai-Liang
AU  - Fu KL
AD  - Department of Medical Imaging, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, China.
FAU - Liu, Huai-Jun
AU  - Liu HJ
AD  - Department of Medical Imaging, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, China.
FAU - Xing, Fei
AU  - Xing F
AD  - Department of Medical Imaging, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, China.
FAU - Zhang, Song-Yun
AU  - Zhang SY
AD  - Department of Endocrinology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, China.
LA  - eng
PT  - Journal Article
DEP - 20141001
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/pathology/*physiopathology
MH  - Brain Mapping
MH  - Cognition/*physiology
MH  - Diabetes Mellitus, Type 2/pathology/*physiopathology
MH  - Diabetic Angiopathies/pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Rest/physiology
PMC - PMC4182760
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/02 06:00
MHDA- 2016/01/02 06:00
PMCR- 2014/10/01
CRDT- 2014/10/02 06:00
PHST- 2014/02/25 00:00 [received]
PHST- 2014/09/04 00:00 [accepted]
PHST- 2014/10/02 06:00 [entrez]
PHST- 2014/10/02 06:00 [pubmed]
PHST- 2016/01/02 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - PONE-D-14-08794 [pii]
AID - 10.1371/journal.pone.0108883 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 1;9(10):e108883. doi: 10.1371/journal.pone.0108883. 
      eCollection 2014.