PMID- 25272505
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20140929
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 39
IP  - 14
DP  - 2014 Jul
TI  - [Comparative study of Coptidis Rhizoma and Aconiti Kusnezoffii Radix on cell 
      differentiation in lewis lung cancer].
PG  - 2732-8
AB  - Coptidis Rhizoma and Aconiti Kusnezoffii Radix represent hot Chinese medicine and 
      cold Chinese medicine respectively. The purpose of this study is to observe the 
      differentiation effect of Coptidis Rhizoma and Aconiti Kusnezoffii Radix on lewis 
      lung cancer and compare effect of hot Chinese medicine and cold Chinese medicine 
      on tumor progression. In this study, the rat serum containing Coptidis Rhizoma or 
      Aconiti Kusnezoffii Radix was prepared to treat lewis lung cancer cells in vitro, 
      and effects of the serum containing Coptidis Rhizoma or Aconiti Kusnezoffii Radix 
      on cell differentiation, proliferation, adhesion, succinic dehydrogenase (SDH) 
      activity and gap-junction intercellular communication (GJIC) were investigated. 
      In vivo, the subcutaneous implant model and pulmonary metastasis model of lewis 
      lung cancer were established. Tumor bearing mice were taken water decoction of 
      coptis chinensis or aconite by intragastric administration bid for four weeks, 
      and the influences of coptis chinensis and aconite on tumor progression were 
      evaluated by body temperature, blood oxygen saturation, red cell ATPase, blood 
      rheology, intratumor hypoxia, capillary permeability and GJIC. The results showed 
      that the serum containing aconite could induce cell differentiation, inhibit cell 
      proliferation and migration, promote SDH activity and GJIC in lewis lung cancer 
      cells. The serum containing Coptidis Rhizoma increased cell adhesion and 
      decreased SDH activity and GJIC without cell differentiation although it also 
      suppressed cell proliferation. Aconiti Kusnezoffii Radix water decoction could 
      keep body temperature, blood oxygen saturation, red cell ATPase and blood 
      rheology, and improve intratumor hypoxia, capillary permeability and GJIC in 
      tumor bearing mice, which led to slower tumor growth and less metastasis. 
      Coptidis Rhizoma water decoction decreased body temperature, blood oxygen 
      saturation, red cell ATPase, blood rheology and GJIC, and promoted intratumor 
      hypoxia and capillary permeability, which resulted to more tumor metastasis 
      although it also prevented tumor growth. These results suggested that the hot 
      Chinese medicine could induce tumor cell differentiation and prevent tumor poison 
      invagination, which is better for tumor treatment than cold Chinese medicine.
FAU - Zhao, Bei
AU  - Zhao B
FAU - Hou, Xi-Dong
AU  - Hou XD
FAU - Li, Hong
AU  - Li H
FAU - Qi, Xiao-Xiao
AU  - Qi XX
FAU - Li, Gang-Gang
AU  - Li GG
FAU - Liu, Lin-Xin
AU  - Liu LX
FAU - Wang, Pei
AU  - Wang P
FAU - Du, Gang-Jun
AU  - Du GJ
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Aconitum/*chemistry
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Carcinoma, Lewis Lung/*pathology
MH  - Cell Differentiation/*drug effects
MH  - Cell Line, Tumor
MH  - Curcuma/*chemistry
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Rats
MH  - Xenograft Model Antitumor Assays
EDAT- 2014/10/03 06:00
MHDA- 2014/10/21 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2014 Jul;39(14):2732-8.