PMID- 25272845
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20211203
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 39
IP  - 11
DP  - 2014 Jun
TI  - [Study on effect of astragali radix polysaccharides in improving learning and 
      memory functions in aged rats and its mechanism].
PG  - 2071-5
AB  - To observe the effect of Astragali Radix polysaccharides (APS) on the learning 
      and memory functions of aged rats, in order to explore its mechanism for 
      improving the learning and memory functions. Natural aging female SD rats were 
      selected in the animal model and randomly divided into the control group, the APS 
      low-dose group (50 mg x kg(-1)), the APS high-dose group (150 mg x kg(-1)) and 
      the piracetam-treated group (560 mg x kg(-1)). They were orally administered with 
      the corresponding drugs for consecutively 60 days. Besides, a young control group 
      was set. The learning and memory functions of the rats were tested by the 
      open-field test and the Morris water maze task. The Western-blot method was used 
      to observe the levels of relevant neural plasticity protein N-methyl-D-aspartate 
      receptor (NMDA receptor) in hippocampus, calcium/calmodulin dependent protein 
      kinase II (CaMK II), protein kinase (PKA), the phosphorylation level of CAMP 
      response element binding protein (CREB) and the protein expression of brain 
      derived neurotrophic factor(BDNF). In this study, the authors found that the 
      learning and memory functions and the hippocampus neural plasticity protein 
      expression of the aged rat group were much lower than that of the young control 
      group (P < 0.01). Compared with the aged rat group, the APS group showed the 
      significant improvement in the impaired learning and memory functions of aged 
      rats and the up-regulation in the hippocampus neural plasticity protein 
      expression. The results showed that APS may improve the learning and memory 
      functions of aged rats by increasing the expressions of relevant neural 
      plasticity proteins.
FAU - Yao, Hui
AU  - Yao H
FAU - Gu, Li-Jia
AU  - Gu LJ
FAU - Guo, Jian-You
AU  - Guo JY
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Polysaccharides)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 922OP8YUPF (Huang Qi)
SB  - IM
MH  - Aging/drug effects/metabolism/*psychology
MH  - Animals
MH  - Astragalus Plant/chemistry
MH  - Astragalus propinquus
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Drugs, Chinese Herbal/chemistry/*pharmacology
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Learning/*drug effects
MH  - Memory/*drug effects
MH  - Polysaccharides/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
EDAT- 2014/10/03 06:00
MHDA- 2014/10/29 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(11):2071-5.