PMID- 25272852
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20141002
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 39
IP  - 11
DP  - 2014 Jun
TI  - [Effect of jiaotai pill on pancreatic fat accumulation and islet cell apoptosis 
      in rats with type 2 diabetes].
PG  - 2106-11
AB  - In this study, the rat type 2 diabetes mellitus (T2DM) model was established 
      through tail vein injection with low dose of streptozotocin (STZ) and high fat 
      diet for 8 weeks, and then treated with Jiaotai Pill. The oral glucose tolerance 
      test (OGTT), fasting serum insulin (FINS), free fatty acid(FFA) levels and blood 
      lipid were assayed. HOMA-IR was calculated. Pancreatic pathology was performed. 
      And pancreatic triglyceride (TG) content was examined by the lipid extraction 
      method. Pancreatic islet cell apoptosis were detected by terminal dexynucleotidyl 
      transferase (TdT)-mediated dUTP nick end labeling (TUNEL). According to the 
      results, the model group showed abnormal OGTT, increased FINS, HOMA-IR, FFA, 
      lipid disorder, obvious fat accumulation and significantly increased TG content 
      in pancreatic tissues, and enhanced pancreatic islet cell apoptosis. Compared 
      with the model group, the Jiaotai Pill group displayed improved OGTT, reduced 
      FINS, HOMA-IR, FFA, recovered lipid disorder, decreased fat accumulation and 
      significantly declined TG content in pancreatic tissues, and lowered pancreatic 
      islet cell apoptosis. In summary, Jiaotai pill could effectively treat type 2 
      diabetes in rats. Its mechanism may be related to the reduction in pancreatic fat 
      accumulation and islet cell apoptosis.
FAU - Zou, Xin
AU  - Zou X
FAU - Liu, De-Liang
AU  - Liu DL
FAU - Lu, Fu-Er
AU  - Lu FE
FAU - Dong, Hui
AU  - Dong H
FAU - Xu, Li-Jun
AU  - Xu LJ
FAU - Luo, Yun-Huan
AU  - Luo YH
FAU - Wang, Kai-Fu
AU  - Wang KF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Fats)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism/physiopathology
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Fats/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Islets of Langerhans/cytology/*drug effects
MH  - Male
MH  - Pancreas/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2014/10/03 06:00
MHDA- 2014/10/29 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(11):2106-11.