PMID- 25272859
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20141120
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 39
IP  - 11
DP  - 2014 Jun
TI  - [Pharmacokinetics behavior of raltitrexed in rats after repeatedly injected with 
      Huangqi injection].
PG  - 2140-3
AB  - In this study, the variation of pharmacokinetics behavior of raltitrexed (RTX) in 
      rats after repeatedly injected with Huangqi injection was investigated. Twelve SD 
      rats were divided into two groups: the multidose group and the RTX group. Rats in 
      multidose group were iv. injected with Huangqi injection (dose of 1.575 mL x 
      kg(-1)) everyday at 8 am for a week, and had free accesses for food and water. 
      The rats were fasted for food but not water since 8 h before the eighth day. At 
      the eighth morning, firstly, rats were injected with Huangqi injection (dose of 
      1.575 mL x kg(-1)), and 5 min later, were injected with RTX (dose of 0.467 mg x 
      kg(-1)); rats in RTX group were not disposed in the previous seven days, also had 
      free accesses for food and water, and were iv. injected with raltitrexed at the 
      same time as Multidose group at the eighth day morning. Rat plasma was collected 
      at different time and processed with methanol to precipitate the protein before 
      HPLC assays. The pharmacokinetics parameters for two groups were calculated by 
      software 3P97. Through the observation of drug concentration in plasma and time 
      curve, we found that at almost every time point the concentration of RTX in 
      plasma in multidose group was lower than the RTX group. When comparing the 
      pharmacokinetics parameters between the multidose group and the RTX group, the 
      average of AUC(0-t) and half-life(t1/2) of multidose group were decreased from 56 
      080 microg x min x L(-1) and 15.07 min to 35 834 microg x min x L(-1) and 8.95 
      min, respectively, while the clearance (CL) was increased from 0.51 to 0.83 mL x 
      h(-1). Therefore, it could be deduced that repeatedly injected with AR injection 
      may influence the renal excretion and glycometabolism of RTX, thus change 
      pharmacokinetics behavior of raltitrexed in rats plasma. This result may give us 
      a hint to prudantly manage the drug combination of RTX and Huangqi injection.
FAU - Xing, Rong
AU  - Xing R
FAU - Qu, Biao
AU  - Qu B
FAU - Song, Jia-Wei
AU  - Song JW
FAU - Zhou, Kai
AU  - Zhou K
FAU - Liao, Qiao
AU  - Liao Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Quinazolines)
RN  - 0 (Thiophenes)
RN  - FCB9EGG971 (raltitrexed)
SB  - IM
MH  - Animals
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacokinetics
MH  - Female
MH  - Injections
MH  - Male
MH  - Quinazolines/administration & dosage/blood/*pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiophenes/administration & dosage/blood/*pharmacokinetics
EDAT- 2014/10/03 06:00
MHDA- 2014/10/29 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(11):2140-3.