PMID- 25272992 OWN - NLM STAT- MEDLINE DCOM- 20151015 LR - 20211021 IS - 1743-8977 (Electronic) IS - 1743-8977 (Linking) VI - 11 DP - 2014 Oct 2 TI - Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study. PG - 51 LID - 10.1186/s12989-014-0051-7 [doi] LID - 51 AB - BACKGROUND: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respiratory effects remains under-investigated. We evaluated the effects of traffic-related PM(2.5) and its elemental components on lung function in two highly exposed groups of healthy adults in Beijing, China. METHODS: The Beijing Truck Driver Air Pollution Study (BTDAS) included 60 truck drivers and 60 office workers evaluated in 2008. On two days separated by 1-2 weeks, we measured lung function at the end of the work day, personal PM(2.5), and nine elemental components of PM(2.5) during eight hours of work, i.e., elemental carbon (EC), potassium (K), sulfur (S), iron (Fe), silicon (Si), aluminum (Al), zinc (Zn), calcium (Ca), and titanium (Ti). We used covariate-adjusted mixed-effects models including PM(2.5) as a covariate to estimate the percentage change in lung function associated with an inter-quartile range (IQR) exposure increase. RESULTS: The two groups had high and overlapping exposure distributions with mean personal PM(2.5) of 94.6 mug/m(3) (IQR: 48.5-126.6) in office workers and 126.8 mug/m(3) (IQR: 73.9-160.5) in truck drivers. The distributions of the nine elements showed group-specific profiles and generally higher levels in truck drivers. In all subjects combined, forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) did not significantly correlate with PM(2.5). However, FEV1 showed negative associations with concentrations of four elements: Si (-3.07%, 95% CI: -5.00; -1.11, IQR: 1.54), Al (-2.88%, 95% CI: -4.91; -0.81, IQR: 0.86), Ca (-1.86%, 95% CI: -2.95; -0.76, IQR: 1.33), and Ti (-2.58%, 95% CI: -4.44; -0.68, IQR: 0.03), and FVC showed negative associations with concentrations of three elements: Si (-3.23%, 95% CI: -5.61; -0.79), Al (-3.26%, 95% CI: -5.73; -0.72), and Ca (-1.86%, 95% CI: -3.23; -0.47). In stratified analysis, Si, Al, Ca, and Ti showed associations with lung function only among truck drivers, and no significant association among office workers. CONCLUSION: Selected elemental components of PM(2.5) showed effects on lung function that were not found in analyses of particle levels alone. FAU - Baccarelli, Andrea A AU - Baccarelli AA AD - Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. abaccare@hsph.harvard.edu. FAU - Zheng, Yinan AU - Zheng Y AD - Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. y-zheng@northwestern.edu. FAU - Zhang, Xiao AU - Zhang X AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. xiao-zhang@northwestern.edu. FAU - Chang, Dou AU - Chang D AD - Department of Safety Engineering, China Institute of Industrial Health, Beijing, China. changdou2004@sohu.com. FAU - Liu, Lei AU - Liu L AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. lei.liu@northwestern.edu. FAU - Wolf, Katherine Rose AU - Wolf KR AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. wolf@northwestern.edu. FAU - Zhang, Zhou AU - Zhang Z AD - Driskill Graduate Program in Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. zhou.zhang@northwestern.edu. FAU - McCracken, John P AU - McCracken JP AD - Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. jmccrack@hsph.harvard.edu. FAU - Diaz, Anaite AU - Diaz A AD - Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. adiaz@ces.uvg.edu.gt. FAU - Bertazzi, Pier Alberto AU - Bertazzi PA AD - Center of Molecular and Genetic Epidemiology, Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca' Granda, Ospedale Maggiore Policlinico, Italy. pieralberto.bertazzi@unimi.it. FAU - Schwartz, Joel AU - Schwartz J AD - Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. jschwrtz@hsph.harvard.edu. FAU - Wang, Sheng AU - Wang S AD - Department of Occupational and Environmental Health, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China. shengw@bjmu.edu.cn. FAU - Kang, Choong-Min AU - Kang CM AD - Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. cmkang@hsph.harvard.edu. FAU - Koutrakis, Petros AU - Koutrakis P AD - Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. petros@hsph.harvard.edu. FAU - Hou, Lifang AU - Hou L AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. l-hou@northwestern.edu. AD - Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. l-hou@northwestern.edu. LA - eng GR - R21 ES020984/ES/NIEHS NIH HHS/United States GR - R21ES020984/ES/NIEHS NIH HHS/United States GR - 1R21ES020010/ES/NIEHS NIH HHS/United States GR - R21 ES020010/ES/NIEHS NIH HHS/United States GR - ES000002/ES/NIEHS NIH HHS/United States GR - R01ES021733/ES/NIEHS NIH HHS/United States GR - P30 ES000002/ES/NIEHS NIH HHS/United States GR - R01 ES021733/ES/NIEHS NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20141002 PL - England TA - Part Fibre Toxicol JT - Particle and fibre toxicology JID - 101236354 RN - 0 (Particulate Matter) RN - 0 (Vehicle Emissions) RN - CPD4NFA903 (Aluminum) RN - D1JT611TNE (Titanium) RN - SY7Q814VUP (Calcium) RN - Z4152N8IUI (Silicon) SB - IM MH - Adult MH - Air Pollution/*adverse effects MH - Aluminum/administration & dosage/analysis/toxicity MH - Calcium/administration & dosage/analysis/toxicity MH - China MH - Environmental Illness/*chemically induced/physiopathology MH - Female MH - Forced Expiratory Volume/drug effects MH - Humans MH - Inhalation Exposure/*adverse effects MH - Lung/*drug effects/physiopathology MH - Lung Diseases/*chemically induced/physiopathology MH - Male MH - Occupations MH - Particulate Matter/administration & dosage/analysis/chemistry/*toxicity MH - Respiratory Mucosa/drug effects/physiopathology MH - Silicon/administration & dosage/analysis/toxicity MH - Statistics as Topic MH - Titanium/administration & dosage/analysis/toxicity MH - *Urban Health MH - Vehicle Emissions/analysis/toxicity MH - Vital Capacity/drug effects PMC - PMC4192276 EDAT- 2014/10/03 06:00 MHDA- 2015/10/16 06:00 PMCR- 2014/10/02 CRDT- 2014/10/03 06:00 PHST- 2014/03/03 00:00 [received] PHST- 2014/09/15 00:00 [accepted] PHST- 2014/10/03 06:00 [entrez] PHST- 2014/10/03 06:00 [pubmed] PHST- 2015/10/16 06:00 [medline] PHST- 2014/10/02 00:00 [pmc-release] AID - s12989-014-0051-7 [pii] AID - 51 [pii] AID - 10.1186/s12989-014-0051-7 [doi] PST - epublish SO - Part Fibre Toxicol. 2014 Oct 2;11:51. doi: 10.1186/s12989-014-0051-7.