PMID- 25273694
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20150317
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 45
IP  - 6
DP  - 2015 Apr
TI  - Altered performance in attention tasks in patients with seasonal allergic 
      rhinitis: seasonal dependency and association with disease characteristics.
PG  - 1289-99
LID - 10.1017/S0033291714002384 [doi]
AB  - BACKGROUND: Seasonal allergic rhinitis (SAR) is a chronic disease affecting about 
      23% of the European population with increasing prevalence rates. Beside classical 
      symptoms (i.e., sneezing, nasal congestion), patients frequently complain about 
      subjective impairments in cognitive functioning during periods of acute allergic 
      inflammation. However, objective evidence for such deficits or the role of 
      potential modulators and underlying mechanisms is limited. The present study 
      aimed to investigate the effect of SAR on attention-related cognitive processes. 
      In addition, relationships between attention performance, sleep and mood 
      disturbances as well as specific disease characteristics as potential modulators 
      of this link were explored. METHOD: SAR patients (n = 41) and non-allergic 
      healthy controls (n = 42) completed a set of attention tasks during a symptomatic 
      allergy period and during a non-symptomatic period. Influences of sleep, mood, 
      total immunoglobulin E (IgE) levels and individual allergy characteristics on 
      cognitive performance were evaluated. RESULTS: Compared to healthy controls, SAR 
      patients had a slower processing speed during both symptomatic and 
      non-symptomatic allergy periods. Additionally, they showed a more flexible 
      adjustment in attention control, which may serve as a compensatory strategy. 
      Reduction in processing speed was positively associated with total IgE levels 
      whereas flexible adjustment of attention was linked with anxious mood. No 
      association was found between SAR-related attention deficits and allergy 
      characteristics or sleep. CONCLUSIONS: SAR represents a state that is crucially 
      linked to impairments in information processing and changes in attentional 
      control adjustments. These cognitive alterations are more likely to be influenced 
      by mood and basal inflammatory processes than sleep impairments or subjective 
      symptom severity.
FAU - Trikojat, K
AU  - Trikojat K
AD  - Department of Psychology,Technische Universitat Dresden,Germany.
FAU - Buske-Kirschbaum, A
AU  - Buske-Kirschbaum A
AD  - Department of Psychology,Technische Universitat Dresden,Germany.
FAU - Schmitt, J
AU  - Schmitt J
AD  - Centre for Evidence-Based Healthcare,University Hospital Carl Gustav Carus 
      Dresden,Germany.
FAU - Plessow, F
AU  - Plessow F
AD  - Department of Psychology,Technische Universitat Dresden,Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141002
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Affect/physiology
MH  - Attention/*physiology
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Psychomotor Performance/*physiology
MH  - Rhinitis, Allergic, Seasonal/immunology/*physiopathology
MH  - Sleep/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - seasonal allergic rhinitis.
EDAT- 2014/10/03 06:00
MHDA- 2015/12/23 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - S0033291714002384 [pii]
AID - 10.1017/S0033291714002384 [doi]
PST - ppublish
SO  - Psychol Med. 2015 Apr;45(6):1289-99. doi: 10.1017/S0033291714002384. Epub 2014 
      Oct 2.