PMID- 25273921
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150204
LR  - 20211021
IS  - 1568-5888 (Print)
IS  - 1876-6250 (Electronic)
IS  - 1568-5888 (Linking)
VI  - 23
IP  - 2
DP  - 2015 Feb
TI  - Left ventricular assist device for end-stage heart failure: results of the first 
      LVAD destination program in the Netherlands.
PG  - 102-8
LID - 10.1007/s12471-014-0602-4 [doi]
AB  - PURPOSE: Mechanical circulatory support with a continuous-flow left ventricular 
      assist device (LVAD) may be a valuable treatment in end-stage heart failure 
      patients for an extended period of time. The purpose of this study was to 
      evaluate the safety and efficacy of implantation of a continuous-flow LVAD in 
      end-stage heart failure patients within the first destination program in the 
      Netherlands. METHODS: A third-generation LVAD was implanted in 16 heart failure 
      patients (age 61 +/- 8; 81 % male; left ventricular ejection fraction 20 +/- 6 %) as 
      destination therapy. All patients were ineligible for heart transplant. At 
      baseline, 3 and 6 months, New York Heart Association (NYHA) functional class, 
      quality-of-life and exercise capacity were assessed. Clinical adverse events were 
      registered. RESULTS: Survival at 30 days and 6 months was 88 and 75 %, 
      respectively. In the postoperative phase, 6 (38 %) patients required continuous 
      veno-venous haemofiltration for renal failure and 2 (13 %) patients required 
      extracorporeal membrane oxygenation because of severe right ventricular failure. 
      During follow-up, NYHA functional class and quality-of-life improved from 
      3.7 +/- 0.1 to 2.3 +/- 0.1 and 57 +/- 5 to 23 +/- 3 at 6 months (P < 0.001), 
      respectively. The 6 min walking distance improved from 168 +/- 42 m to 291 +/- 29 m 
      at 6 months (P = 0.001). CONCLUSION: Continuous-flow LVAD therapy is a promising 
      treatment for patients with end-stage heart failure ineligible for heart 
      transplant.
FAU - Haeck, M L A
AU  - Haeck ML
AD  - Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 
      ZA, Leiden, the Netherlands.
FAU - Beeres, S L M A
AU  - Beeres SL
FAU - Hoke, U
AU  - Hoke U
FAU - Palmen, M
AU  - Palmen M
FAU - Couperus, L E
AU  - Couperus LE
FAU - Delgado, V
AU  - Delgado V
FAU - Logeman, E A
AU  - Logeman EA
FAU - Maas, J J
AU  - Maas JJ
FAU - Klautz, R J M
AU  - Klautz RJ
FAU - Schalij, M J
AU  - Schalij MJ
FAU - Verwey, H F
AU  - Verwey HF
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neth Heart J
JT  - Netherlands heart journal : monthly journal of the Netherlands Society of 
      Cardiology and the Netherlands Heart Foundation
JID - 101095458
PMC - PMC4315784
EDAT- 2014/10/03 06:00
MHDA- 2014/10/03 06:01
PMCR- 2014/10/02
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/03 06:01 [medline]
PHST- 2014/10/02 00:00 [pmc-release]
AID - 602 [pii]
AID - 10.1007/s12471-014-0602-4 [doi]
PST - ppublish
SO  - Neth Heart J. 2015 Feb;23(2):102-8. doi: 10.1007/s12471-014-0602-4.