PMID- 25274212
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20190724
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 134
IP  - 10
DP  - 2014
TI  - [Effects of genetic and environmental factors on neuropsychological development].
PG  - 1029-35
AB  - Abnormalities in early brain development contribute to the etiology of many 
      neurological disorders in later life. Recent advances in genome analysis indicate 
      that large numbers of common gene variants shape any individual's disease risk, 
      including that for major mental illnesses. Polyriboinosinic-polyribocytidilic 
      acid (polyI:C) is known to induce strong innate immune responses that mimic 
      immune activation by viral infections. Our previous findings suggest that 
      activation of the innate immune system in astrocytes results in impairments of 
      neurite outgrowth and spine formation, which lead to behavioral abnormalities in 
      adulthood. Although glial cells are classically thought to provide structural and 
      metabolic support to neurons, they are now widely recognized as essential 
      regulators of neuronal development including neuronal migration, axon and 
      dendrite growth, formation of synapses, and synaptic plasticity. Astrocytes also 
      play critical roles in regulating CNS immune function by responding to 
      inflammatory mediators and producing additional cytokines and chemokines. Most of 
      the functions of astrocytes are mediated by the release of humoral factors 
      through a close interaction with neurons. However, the mechanism by which innate 
      immune activation of astrocytes affects neuronal development remains to be 
      determined. To explore the alteration in proteins secreted from murine astrocytes 
      after polyI:C stimulation, astrocyte-conditioned medium (ACM) was analyzed by 
      2-dimensional fluorescence difference gel electrophoresis (2D-DIGE). We 
      identified matrix metalloproteinase-3 (Mmp3) as a potential mediator of 
      polyI:C/ACM-induced neurodevelopmental impairment. Here, we provide an overview 
      of the mechanism of neurodevelopmental impairment following polyI:C-induced 
      innate immune activation of astrocytes.
FAU - Nagai, Taku
AU  - Nagai T
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      Graduate School of Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/cytology/enzymology
MH  - Humans
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Neurons/cytology/enzymology
MH  - Personality Development
MH  - *Psychology, Developmental
MH  - Social Behavior
EDAT- 2014/10/03 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - DN/JST.JSTAGE/yakushi/14-00182 [pii]
AID - 10.1248/yakushi.14-00182 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2014;134(10):1029-35. doi: 10.1248/yakushi.14-00182.