PMID- 25274437
OWN - NLM
STAT- MEDLINE
DCOM- 20150626
LR  - 20231111
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 28
IP  - 5
DP  - 2014 Sep-Oct
TI  - A retrospective study of 1,098 blood samples with anemia from adult cats: 
      frequency, classification, and association with serum creatinine concentration.
PG  - 1391-7
LID - 10.1111/jvim.12422 [doi]
AB  - BACKGROUND: Frequency and classification of anemia in terms of regeneration 
      status and erythrocyte indices are not well described in cats. OBJECTIVE: To 
      determine frequency and regenerative status of anemia in samples from adult cats, 
      to assess the sensitivity and specificity of macrocytosis and hypochromasia for 
      detecting regenerative anemia (RA), and to evaluate the association of anemia 
      with increased serum creatinine concentration (SC). STUDY POPULATION: Laboratory 
      records from 30,503 blood samples from cats (2003-2011). METHODS: 
      Clinicopathologic data reviewed retrospectively. Anemia defined as hematocrit 
      (Ht) </=27%, red blood cell count (RBC) </=5.5 x 10(6)/muL and hemoglobin (Hb) </=9.0 
      g/dL. RA defined by manual absolute reticulocyte count >50 x 10(3)/muL. 
      Macrocytosis was defined as mean corpuscular volume (MCV) >55 fL and 
      hypochromasia as mean corpuscular hemoglobin concentration (MCHC) <31 g/dL. 
      Cutoff for increased serum creatinine concentration was 1.6 mg/dL. RESULTS: 
      Overall, 1,098 of 30,503 blood samples (3.6%) from cats fulfilled criteria for 
      anemia, 633 of 1,098 (57.7%) classified as nonregenerative (NRA) and 465 of 1,098 
      (42.3%) as regenerative. RBC, Ht, and Hb were significantly lower in the RA 
      compared to NRA group (P < .05). Sensitivity and specificity of the combined high 
      MCV and low MCHC to detect samples with RA were 19.5 and 90.7%. SC was increased 
      in 572 of the 1,098 anemic samples (52.1%) and in 11,121 of 29,405 of nonanemic 
      samples (37.8%). CONCLUSIONS AND CLINICAL IMPORTANCE: Majority of anemic samples 
      were classified as NRA. Anemia was more severe in cats with RA. Erythrocyte 
      indices were not sensitive indicators of RA.
CI  - Copyright (c) 2014 by the American College of Veterinary Internal Medicine.
FAU - Furman, E
AU  - Furman E
AD  - Laboratory InVitro GmbH, Vienna, Austria.
FAU - Leidinger, E
AU  - Leidinger E
FAU - Hooijberg, E H
AU  - Hooijberg EH
FAU - Bauer, N
AU  - Bauer N
FAU - Beddies, G
AU  - Beddies G
FAU - Moritz, A
AU  - Moritz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Anemia/blood/classification/diagnosis/*veterinary
MH  - Anemia, Hypochromic/blood/diagnosis/veterinary
MH  - Anemia, Macrocytic/blood/diagnosis/veterinary
MH  - Animals
MH  - Blood Cell Count/veterinary
MH  - Cat Diseases/*blood/diagnosis
MH  - Cats/blood
MH  - Creatinine/*blood
MH  - Female
MH  - Hematocrit/veterinary
MH  - Male
MH  - Retrospective Studies
PMC - PMC4895589
OTO - NOTNLM
OT  - Erythrocyte indices
OT  - Nonregenerative
OT  - Regenerative
OT  - Reticulocytes
EDAT- 2014/10/03 06:00
MHDA- 2015/06/27 06:00
PMCR- 2014/09/01
CRDT- 2014/10/03 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2014/05/23 00:00 [revised]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2015/06/27 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - JVIM12422 [pii]
AID - 10.1111/jvim.12422 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2014 Sep-Oct;28(5):1391-7. doi: 10.1111/jvim.12422.