PMID- 25274499
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150212
LR  - 20240512
IS  - 2052-0034 (Print)
IS  - 2052-0034 (Electronic)
VI  - 3
IP  - 1
DP  - 2015 Feb
TI  - Refractory gastroesophageal reflux disease.
PG  - 41-53
LID - 10.1093/gastro/gou061 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a condition that develops when the 
      reflux of stomach contents into the esophagus causes troublesome symptoms, 
      esophageal injury, and/or complications. Use of proton pump inhibitors (PPI) 
      remains the standard therapy for GERD and is effective in most patients. Those 
      whose symptoms are refractory to PPIs should be evaluated further and other 
      treatment options should be considered, according to individual patient 
      characteristics. Response to PPIs could be total (no symptoms), partial (residual 
      breakthrough symptoms), or absent (no change in symptoms). Patients experiencing 
      complete response do not usually need further management. Patients with partial 
      response can be treated surgically or by using emerging endoscopic therapies. 
      Patients who exhibit no response to PPI need further evaluation to rule out other 
      causes.
CI  - (c) The Author(s) 2014. Published by Oxford University Press and the Digestive 
      Science Publishing Co. Limited.
FAU - Subramanian, Charumathi Raghu
AU  - Subramanian CR
AD  - Internal Medicine, Guthrie Clinic, Sayre, PA, USA and Division of 
      Gastroenterology, Stanford University School of Medicine, Stanford, CA, USA.
FAU - Triadafilopoulos, George
AU  - Triadafilopoulos G
AD  - Internal Medicine, Guthrie Clinic, Sayre, PA, USA and Division of 
      Gastroenterology, Stanford University School of Medicine, Stanford, CA, USA 
      vagt@stanford.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140930
PL  - England
TA  - Gastroenterol Rep (Oxf)
JT  - Gastroenterology report
JID - 101620508
PMC - PMC4324866
OTO - NOTNLM
OT  - acid-related diseases
OT  - endoscopy
OT  - gastroesophageal reflux disease
OT  - pH monitoring
EDAT- 2014/10/03 06:00
MHDA- 2014/10/03 06:01
PMCR- 2015/02/01
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/03 06:01 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - gou061 [pii]
AID - 10.1093/gastro/gou061 [doi]
PST - ppublish
SO  - Gastroenterol Rep (Oxf). 2015 Feb;3(1):41-53. doi: 10.1093/gastro/gou061. Epub 
      2014 Sep 30.