PMID- 25274590
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20211021
IS  - 1319-6138 (Print)
IS  - 1319-6138 (Electronic)
IS  - 1319-6138 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Oct
TI  - Association between human leukocyte antigen-DR and demylinating Guillain-Barre 
      syndrome.
PG  - 301-5
AB  - OBJECTIVE: To find an association between human leukocyte antigen (HLA) class II 
      DRB1, DRB3, DRB4, and DRB5 alleles frequencies in a sample of Iraqi patients with 
      Guillain-Barre syndrome (GBS) and compare with a healthy control group. METHODS: 
      We performed a cross-sectional study consisting of 30 Iraqi Arab patients with 
      GBS attending the Neurological Department in the Neuroscience Hospital, Baghdad, 
      Iraq between September 2012 and June 2013. The control group comprised 42 
      apparently healthy volunteers. Human leukocyte antigen genotyping for HLA DRB1, 
      DRB3, DRB4, and DRB5 was performed using the polymerase chain 
      reaction-sequence-specific primers method. The allele frequencies were compared 
      across both groups. Major histocompatibility complex (MHC)-class II HLA-DR 
      genotyping and serotyping were performed by software analysis. RESULTS: We found 
      increased frequencies of HLA genotype DRB1*03:01 (p=0.0009), DRB1*07:01 
      (p=0.0015), and DRB4*01:01 (p<0.0001) in patients with GBS compared with healthy 
      controls. The HLA DR6 was increased in the control group (p<0.0001). CONCLUSION: 
      Our results suggest an association between HLA-DRB1*03:01, DRB1*07:01, 
      DRB4*01:01, and HLA DR3, DR7 and a susceptibility to GBS.
FAU - Hasan, Zaki N
AU  - Hasan ZN
AD  - HLA Typing Research Unit, Al-Kindy College of Medicine, Baghdad University, 
      Baghdad, Iraq.
FAU - Zalzala, Haider H
AU  - Zalzala HH
FAU - Mohammedsalih, Hyam R
AU  - Mohammedsalih HR
FAU - Mahdi, Batool M
AU  - Mahdi BM
FAU - Abid, Laheeb A
AU  - Abid LA
FAU - Shakir, Zena N
AU  - Shakir ZN
FAU - Fadhel, Maithem J
AU  - Fadhel MJ
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Neurosciences (Riyadh)
JT  - Neurosciences (Riyadh, Saudi Arabia)
JID - 101252453
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB4*01:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arabs/genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Guillain-Barre Syndrome/epidemiology/*genetics/immunology
MH  - HLA-DR Antigens/*analysis/genetics
MH  - HLA-DRB1 Chains/analysis/genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Iraq/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC4727669
EDAT- 2014/10/03 06:00
MHDA- 2015/01/06 06:00
PMCR- 2014/10/01
CRDT- 2014/10/03 06:00
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - Neurosciences-19-301 [pii]
PST - ppublish
SO  - Neurosciences (Riyadh). 2014 Oct;19(4):301-5.