PMID- 25276349
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141003
LR  - 20211021
IS  - 2047-9158 (Print)
IS  - 2047-9158 (Electronic)
IS  - 2047-9158 (Linking)
VI  - 3
DP  - 2014
TI  - Chaperone-mediated autophagy: roles in neurodegeneration.
PG  - 20
LID - 10.1186/2047-9158-3-20 [doi]
AB  - Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with 
      an exposed CMA-targeting motif to lysosomes for degradation and plays an 
      important role in protein quality control and cellular homeostasis. A growing 
      body of evidence supports the hypothesis that CMA dysfunction may be involved in 
      the pathogenic process of neurodegenerative diseases. Both down-regulation and 
      compensatory up-regulation in CMA activities have been observed in association 
      with neurodegenerative conditions. Recent studies have revealed several new 
      mechanisms by which CMA function may be involved in the regulation of factors 
      critical for neuronal viability and homeostasis. Here, we summarize these recent 
      advances in the understanding of the relationship between CMA dysfunction and 
      neurodegeneration and discuss the therapeutic potential of targeting CMA in the 
      treatment of neurodegenerative diseases.
FAU - Wang, Gang
AU  - Wang G
AD  - Departments of Pharmacology and Neurology, Emory University School of Medicine, 
      Atlanta, GA 30322, USA ; Center for Neurodegenerative Diseases, Emory University 
      School of Medicine, Atlanta, GA 30322, USA.
FAU - Mao, Zixu
AU  - Mao Z
AD  - Departments of Pharmacology and Neurology, Emory University School of Medicine, 
      Atlanta, GA 30322, USA ; Center for Neurodegenerative Diseases, Emory University 
      School of Medicine, Atlanta, GA 30322, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140921
PL  - England
TA  - Transl Neurodegener
JT  - Translational neurodegeneration
JID - 101591861
PMC - PMC4177711
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Chaperone-mediated autophagy
OT  - Neurodegeneration
OT  - Parkinson's disease
OT  - Protein posttranslational modifications
EDAT- 2014/10/03 06:00
MHDA- 2014/10/03 06:01
PMCR- 2014/09/21
CRDT- 2014/10/03 06:00
PHST- 2014/07/29 00:00 [received]
PHST- 2014/09/18 00:00 [accepted]
PHST- 2014/10/03 06:00 [entrez]
PHST- 2014/10/03 06:00 [pubmed]
PHST- 2014/10/03 06:01 [medline]
PHST- 2014/09/21 00:00 [pmc-release]
AID - 2047-9158-3-20 [pii]
AID - 10.1186/2047-9158-3-20 [doi]
PST - epublish
SO  - Transl Neurodegener. 2014 Sep 21;3:20. doi: 10.1186/2047-9158-3-20. eCollection 
      2014.