PMID- 25277537
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20220317
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 72
IP  - 3-4
DP  - 2014
TI  - Hyperhomocysteinemia and risk of cognitive decline: a meta-analysis of 
      prospective cohort studies.
PG  - 241-8
LID - 10.1159/000363054 [doi]
AB  - OBJECTIVE: To evaluate the association between hyperhomocysteinemia (HHcy) and 
      risk of cognitive decline. METHODS: Electronic databases such as PubMed and 
      EMBASE were searched for prospective cohort studies that involved the 
      relationship between HHcy and risk of cognitive decline. Adjusted risk ratios 
      (RRs) and corresponding 95% confidence intervals (95% CIs) were calculated by 
      Review Manager 5.2.7. Subgroup analyses were conducted on stratification of some 
      important variables. RESULTS: Fourteen publications were included in the 
      analysis. The pooled RR was 1.53 (95% CI, 1.23-1.91; p = 0.0002) for patients 
      with HHcy compared to subjects without HHcy. Subgroup analyses indicated that the 
      pooled RRs were 1.51 (95% CI, 1.10-2.05; p = 0.01) for more than five-year 
      follow-up studies and 1. 56 (95% CI, 1.13-2.14; p = 0.007) for less than 
      five-year follow-up studies. The pooled RRs were 1.66 (95% CI, 1.21-2.26; p = 
      0.001) for studies excluding the confounder of B vitamins and 1.34 (95% CI, 
      1.08-1.66; p = 0.008) for non-excluded studies. In terms of region, the pooled RR 
      was 1.60 (95% CI, 1.21-2.13; p = 0.001) for European and American countries, 
      while the pooled RR was 1.27 (95% CI, 1.02-1.59; p = 0.03) for other regions. 
      CONCLUSION: As one of the independent risk factors, HHcy was associated with an 
      increased risk of cognitive decline.
CI  - (c) 2014 S. Karger AG, Basel
FAU - Nie, Tian
AU  - Nie T
FAU - Lu, Ting
AU  - Lu T
FAU - Xie, Lu
AU  - Xie L
FAU - Huang, Panpan
AU  - Huang P
FAU - Lu, Yuan
AU  - Lu Y
FAU - Jiang, Minhai
AU  - Jiang M
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cognition Disorders/*complications/*epidemiology
MH  - Cohort Studies
MH  - Databases, Bibliographic/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/*epidemiology
MH  - Male
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2014/10/04 06:00
MHDA- 2015/06/03 06:00
CRDT- 2014/10/04 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
AID - 000363054 [pii]
AID - 10.1159/000363054 [doi]
PST - ppublish
SO  - Eur Neurol. 2014;72(3-4):241-8. doi: 10.1159/000363054.