PMID- 25278127
OWN - NLM
STAT- MEDLINE
DCOM- 20150410
LR  - 20150213
IS  - 1421-9662 (Electronic)
IS  - 0001-5792 (Linking)
VI  - 133
IP  - 2
DP  - 2015
TI  - Acute myeloid leukemia is a disease associated with HLA-C3.
PG  - 164-7
LID - 10.1159/000365436 [doi]
AB  - BACKGROUND: We aimed to observe human leukocyte antigen (HLA) associations with 
      human acute myeloid leukemia (AML) in a large population, in order to investigate 
      the roles of HLA in leukemogenesis. Furthermore, we examined the HLA association 
      according to morphological, cytogenetic, immunological, and clinical 
      classifications. MATERIALS AND METHODS: We performed HLA genotyping, bone marrow 
      studies, cytogenetic analyses, and fluorescence-activated cell sorting analyses. 
      A clinical outcome database was constructed, and the HLA frequency, gene 
      frequency, relative risk (RR), linkage disequilibrium, and the 2-locus and 
      3-locus haplotype frequency using the Mattiuz formula were calculated. For the 
      healthy controls, Korean HLA data published by Park and co-workers were used. 
      RESULTS: AML was found to be associated with HLA-C3 (RR = 1.46; p < 0.001). In 
      the French-American-British (FAB) classification, acute myelomonocytic leukemia 
      (AML-M4) was associated with HLA-C3 (47.2 vs. 74.1%; RR = 3.13; p = 0.005), in 
      cytogenetic classification, del(9), which is frequently observed in AML-M4, was 
      also associated with HLA-C3 (47.2 vs. 100%; RR = 13.43; p = 0.024), and in 
      clinical classification, incomplete remission was associated with HLA-C3 as well 
      (47.2 vs. 63.2%; RR = 1.92; p = 0.002). No correlations between AML and 
      immunological classifications were observed. Moreover, and in terms of 2-locus 
      haplotypes, AML was found to be associated with HLA-C3/B62 (HLA-C3 gene frequency 
      0.3415; HLA-B62 gene frequency 0.1361; linkage disequilibrium 0.0136; haplotype 
      frequency 4.15 vs. 6.0%; p < 0.05). In clinical classification, incomplete 
      remission (linkage disequilibrium 0.0136; haplotype frequency 4.15 vs. 13.6%; p = 
      0.013) and relapse (linkage disequilibrium 0.0136; haplotype frequency 4.15 vs. 
      71.0%; p = 0.044) were associated with HLA-C3/B62, whereas no association was 
      observed for FAB, cytogenetic and immunological classifications. No association 
      was observed for the 3-locus haplotype. CONCLUSION: The HLA-C3 antigen and the 
      2-locus haplotype are associated with AML.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Yoon, Jeongsook
AU  - Yoon J
AD  - Hyundai Medical Clinic Research Center, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20140927
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
CIN - Acta Haematol. 2015;133(2):162-3. PMID: 25278006
MH  - *Databases, Factual
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - *Genetic Loci
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/classification/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Leukemia, Myeloid, Acute/classification/*genetics/mortality/therapy
MH  - *Linkage Disequilibrium
MH  - Male
MH  - Retrospective Studies
EDAT- 2014/10/04 06:00
MHDA- 2015/04/11 06:00
CRDT- 2014/10/04 06:00
PHST- 2014/01/28 00:00 [received]
PHST- 2014/06/24 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/04/11 06:00 [medline]
AID - 000365436 [pii]
AID - 10.1159/000365436 [doi]
PST - ppublish
SO  - Acta Haematol. 2015;133(2):164-7. doi: 10.1159/000365436. Epub 2014 Sep 27.