PMID- 25278335
OWN - NLM
STAT- MEDLINE
DCOM- 20150323
LR  - 20220331
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Print)
IS  - 0031-9023 (Linking)
VI  - 95
IP  - 2
DP  - 2015 Feb
TI  - Safety of aerobic exercise in people with diabetic peripheral neuropathy: 
      single-group clinical trial.
PG  - 223-34
LID - 10.2522/ptj.20140108 [doi]
AB  - BACKGROUND: Exercise is recommended for people with diabetes, but little is known 
      about exercise in people with diabetic peripheral neuropathy (DPN). OBJECTIVE: 
      The primary purpose of this preliminary study was to examine adverse events (AEs) 
      during moderate-intensity, supervised aerobic exercise in people with DPN. The 
      secondary purpose was to examine changes in fatigue, aerobic fitness, and other 
      outcomes after intervention. DESIGN: This was a single-group preliminary study. 
      SETTING: The setting was an academic medical center. PARTICIPANTS: Participants 
      were 18 people who were sedentary and had type 2 diabetes and peripheral 
      neuropathy (mean age=58.1 years, SD=5). INTERVENTION: The intervention was a 
      supervised 16-week aerobic exercise program (3 times per week at 50% to >70% 
      oxygen uptake reserve). MEASUREMENTS: Adverse events were categorized as related 
      or unrelated to the study, anticipated or unanticipated, and serious or not 
      serious. Outcomes included fatigue (Multidimensional Fatigue Inventory), 
      cardiovascular fitness (peak oxygen uptake), body composition (dual-energy x-ray 
      absorptiometry), sleep quality, plasma metabolic markers, and peripheral vascular 
      function. RESULTS: During the study, 57 nonserious AEs occurred. Improvements 
      were found in general fatigue (mean change=-3.5; 95% confidence interval [95% 
      CI]=-1.3, -5.3), physical fatigue (mean change=-3.1; 95% CI=-1.2, -5.0), peak 
      oxygen uptake (mean change=1.1 mL.kg(-1).min(-1); 95% CI=0.2, 1.9), total body 
      fat (mean change=-1%; 95% CI=-0.3, -1.7), fat mass (mean change=-1,780 g; 95% 
      CI=-616.2, -2,938.7), and peripheral blood flow (mean change=2.27%; 95% CI=0.6, 
      4.0). LIMITATIONS: This was a small-scale, uncontrolled study. A future 
      randomized controlled trial is needed to fully assess the effects of exercise on 
      the outcomes. CONCLUSIONS: This study provides new support for supervised aerobic 
      exercise in people with DPN. However, it is important for physical therapists to 
      carefully prescribe initial exercise intensity and provide close monitoring and 
      education to address the anticipated AEs as people who are sedentary and have DPN 
      begin an exercise program.
CI  - (c) 2015 American Physical Therapy Association.
FAU - Kluding, Patricia M
AU  - Kluding PM
AD  - P.M. Kluding, PT, PhD, Physical Therapy and Rehabilitation Sciences, University 
      of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 (USA). 
      pkluding@kumc.edu.
FAU - Pasnoor, Mamatha
AU  - Pasnoor M
AD  - M. Pasnoor, MD, Department of Neurology, University of Kansas Medical Center.
FAU - Singh, Rupali
AU  - Singh R
AD  - R. Singh, PhD, Physical Therapy, The Sage Colleges, Troy, New York.
FAU - D'Silva, Linda J
AU  - D'Silva LJ
AD  - L.J. D'Silva, PT, Physical Therapy and Rehabilitation Sciences, University of 
      Kansas Medical Center.
FAU - Yoo, Min
AU  - Yoo M
AD  - M. Yoo, MS, Physical Therapy and Rehabilitation Sciences, University of Kansas 
      Medical Center.
FAU - Billinger, Sandra A
AU  - Billinger SA
AD  - S.A. Billinger, PT, PhD, Physical Therapy and Rehabilitation Sciences, University 
      of Kansas Medical Center.
FAU - LeMaster, Joseph W
AU  - LeMaster JW
AD  - J.W. LeMaster, MD, MPH, Department of Family Medicine, University of Kansas 
      Medical Center.
FAU - Dimachkie, Mazen M
AU  - Dimachkie MM
AD  - M.M. Dimachkie, MD, FANA, Department of Neurology, University of Kansas Medical 
      Center.
FAU - Herbelin, Laura
AU  - Herbelin L
AD  - L. Herbelin, BSc, PTA, Department of Neurology, University of Kansas Medical 
      Center.
FAU - Wright, Douglas E
AU  - Wright DE
AD  - D.E. Wright, PhD, Department of Anatomy and Cell Biology, University of Kansas 
      Medical Center.
LA  - eng
SI  - ClinicalTrials.gov/NCT01764373
GR  - TL1 TR000120/TR/NCATS NIH HHS/United States
GR  - T32 HD057850/HD/NICHD NIH HHS/United States
GR  - UL1 TR000001/TR/NCATS NIH HHS/United States
GR  - K01HD067318/HD/NICHD NIH HHS/United States
GR  - T32HD057850/HD/NICHD NIH HHS/United States
GR  - TL1TR000120/TR/NCATS NIH HHS/United States
GR  - R01 NS043314/NS/NINDS NIH HHS/United States
GR  - K01 HD067318/HD/NICHD NIH HHS/United States
GR  - UL1TR000001/TR/NCATS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141002
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Composition
MH  - Brachial Artery/physiology
MH  - Diabetic Neuropathies/physiopathology/*rehabilitation
MH  - *Exercise
MH  - Fatigue/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - Registries
MH  - Sedentary Behavior
MH  - Sleep/physiology
MH  - Surveys and Questionnaires
PMC - PMC4757647
EDAT- 2014/10/04 06:00
MHDA- 2015/03/24 06:00
PMCR- 2015/08/01
CRDT- 2014/10/04 06:00
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/03/24 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - ptj.20140108 [pii]
AID - 2014-0108 [pii]
AID - 10.2522/ptj.20140108 [doi]
PST - ppublish
SO  - Phys Ther. 2015 Feb;95(2):223-34. doi: 10.2522/ptj.20140108. Epub 2014 Oct 2.