PMID- 25278483
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20151119
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 37
IP  - 10
DP  - 2014 Dec
TI  - Choroidal neovascularization associated with extensive macular atrophy with 
      pseudodrusen-like appearance.
PG  - 780-6
LID - S0181-5512(14)00265-4 [pii]
LID - 10.1016/j.jfo.2014.06.003 [doi]
AB  - PURPOSE: Extensive macular atrophy with pseudodrusen-like appearance (EMAP) is a 
      recently described entity. We describe the first observations of choroidal 
      neovascularization (CNV) associated with EMAP in 3 patients. METHODS: Nineteen 
      consecutive patients with EMAP were retrospectively investigated for the presence 
      of CNV and treatment outcomes. Each patient underwent a complete ophthalmologic 
      examination including color fundus photograpy, fluorescein angiography (FA), 
      indocyanine green angiography (ICG) and spectral-domain optical coherence 
      tomography (SD-OCT). RESULTS: Retrospective analysis revealed choroidal 
      neovascularization in 3 patients (4 eyes) out of 19 patients with EMAP. In these 
      patients, laser photocoagulation or intravitreal injections of ranibizumab led to 
      resolution of retinal exudation with limited functional improvement. CONCLUSION: 
      CNV is a possible complication of EMAP, a recently reported form of macular 
      atrophy resembling geographic atrophy. Laser photocoagulation and anti-VEGF 
      treatment appear to be two valuable therapeutic options.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Kamami-Levy, C
AU  - Kamami-Levy C
AD  - Department of Ophthalmology, centre hospitalier intercommunal de Creteil, 40, 
      avenue de Verdun, 94010 Creteil, France; Universite Paris-Est, 61, avenue du 
      General-de-Gaulle, 94010 Creteil, France.
FAU - Querques, G
AU  - Querques G
AD  - Department of Ophthalmology, centre hospitalier intercommunal de Creteil, 40, 
      avenue de Verdun, 94010 Creteil, France; Universite Paris-Est, 61, avenue du 
      General-de-Gaulle, 94010 Creteil, France. Electronic address: 
      giuseppe.querques@hotmail.it.
FAU - Rostaqui, O
AU  - Rostaqui O
AD  - Department of Ophthalmology, centre hospitalier intercommunal de Creteil, 40, 
      avenue de Verdun, 94010 Creteil, France; Universite Paris-Est, 61, avenue du 
      General-de-Gaulle, 94010 Creteil, France.
FAU - Blanco-Garavito, R
AU  - Blanco-Garavito R
AD  - Department of Ophthalmology, centre hospitalier intercommunal de Creteil, 40, 
      avenue de Verdun, 94010 Creteil, France; Universite Paris-Est, 61, avenue du 
      General-de-Gaulle, 94010 Creteil, France.
FAU - Souied, E-H
AU  - Souied EH
AD  - Department of Ophthalmology, centre hospitalier intercommunal de Creteil, 40, 
      avenue de Verdun, 94010 Creteil, France; Universite Paris-Est, 61, avenue du 
      General-de-Gaulle, 94010 Creteil, France.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140930
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - ZL1R02VT79 (Ranibizumab)
SB  - IM
MH  - Angiogenesis Inhibitors/administration & dosage
MH  - Antibodies, Monoclonal, Humanized/administration & dosage
MH  - Choroidal Neovascularization/*complications/diagnosis/therapy
MH  - Female
MH  - Geographic Atrophy/*complications/diagnosis/therapy
MH  - Humans
MH  - Intravitreal Injections
MH  - Laser Coagulation
MH  - Male
MH  - Middle Aged
MH  - Ranibizumab
MH  - Retinal Drusen/*complications/diagnosis/therapy
MH  - Retrospective Studies
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
OTO - NOTNLM
OT  - Atrophie geographique
OT  - Choroidal neovascularization
OT  - Drusen
OT  - Dystrophie maculaire
OT  - Geographic atrophy
OT  - Macular dystrophy
OT  - Neovascularisation choroidienne
OT  - Optical coherence tomography
OT  - Pseudodrusen
OT  - Tomographie par coherence optique
EDAT- 2014/10/04 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/10/04 06:00
PHST- 2014/04/04 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2014/06/11 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - S0181-5512(14)00265-4 [pii]
AID - 10.1016/j.jfo.2014.06.003 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2014 Dec;37(10):780-6. doi: 10.1016/j.jfo.2014.06.003. Epub 2014 
      Sep 30.