PMID- 25278846
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20211021
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 8
DP  - 2014
TI  - Regulatory effects of intermittent noxious stimulation on spinal cord 
      injury-sensitive microRNAs and their presumptive targets following spinal cord 
      contusion.
PG  - 117
LID - 10.3389/fncir.2014.00117 [doi]
LID - 117
AB  - Uncontrollable nociceptive stimulation adversely affects recovery in spinally 
      contused rats. Spinal cord injury (SCI) results in altered microRNA (miRNA) 
      expression both at, and distal to the lesion site. We hypothesized that 
      uncontrollable nociception further influences SCI-sensitive miRNAs and associated 
      gene targets, potentially explaining the progression of maladaptive plasticity. 
      Our data validated previously described sensitivity of miRNAs to SCI alone. 
      Moreover, following SCI, intermittent noxious stimulation decreased expression of 
      miR124 in dorsal spinal cord 24 h after stimulation and increased expression of 
      miR129-2 in dorsal, and miR1 in ventral spinal cord at 7 days. We also found that 
      brain-derived neurotrophic factor (BDNF) mRNA expression was significantly 
      down-regulated 1 day after SCI alone, and significantly more so, after SCI 
      followed by tailshock. Insulin-like growth factor-1 (IGF-1) mRNA expression was 
      significantly increased at both 1 and 7 days post-SCI, and significantly more so, 
      7 days post-SCI with shock. MiR1 expression was positively and significantly 
      correlated with IGF-1, but not BDNF mRNA expression. Further, stepwise linear 
      regression analysis indicated that a significant proportion of the changes in 
      BDNF and IGF-1 mRNA expression were explained by variance in two groups of 
      miRNAs, implying co-regulation. Collectively, these data show that uncontrollable 
      nociception which activates sensorimotor circuits distal to the injury site, 
      influences SCI-miRNAs and target mRNAs within the lesion site. SCI-sensitive 
      miRNAs may well mediate adverse consequences of uncontrolled sensorimotor 
      activation on functional recovery. However, their sensitivity to distal sensory 
      input also implicates these miRNAs as candidate targets for the management of SCI 
      and neuropathic pain.
FAU - Strickland, Eric R
AU  - Strickland ER
AD  - Department of Neuroscience and Experimental Therapeutics, College of Medicine, 
      Texas A&M Health Science Center Bryan, TX, USA.
FAU - Woller, Sarah A
AU  - Woller SA
AD  - Department of Psychology, Texas A&M University, College Station TX, USA.
FAU - Garraway, Sandra M
AU  - Garraway SM
AD  - Department of Psychology, Texas A&M University, College Station TX, USA.
FAU - Hook, Michelle A
AU  - Hook MA
AD  - Department of Neuroscience and Experimental Therapeutics, College of Medicine, 
      Texas A&M Health Science Center Bryan, TX, USA.
FAU - Grau, James W
AU  - Grau JW
AD  - Department of Psychology, Texas A&M University, College Station TX, USA.
FAU - Miranda, Rajesh C
AU  - Miranda RC
AD  - Department of Neuroscience and Experimental Therapeutics, College of Medicine, 
      Texas A&M Health Science Center Bryan, TX, USA.
LA  - eng
GR  - R01 HD058412/HD/NICHD NIH HHS/United States
GR  - HD058412/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140918
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/*physiology
MH  - Insulin-Like Growth Factor I/genetics/*metabolism
MH  - Male
MH  - MicroRNAs/*metabolism
MH  - Nociception/*physiology
MH  - Physical Stimulation/adverse effects
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*metabolism
MH  - Statistics as Topic
PMC - PMC4166958
OTO - NOTNLM
OT  - BDNF
OT  - IGF
OT  - microRNA
OT  - spinal cord injury
OT  - uncontrollable nociception
EDAT- 2014/10/04 06:00
MHDA- 2015/05/16 06:00
PMCR- 2014/01/01
CRDT- 2014/10/04 06:00
PHST- 2014/04/18 00:00 [received]
PHST- 2014/09/03 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2014.00117 [doi]
PST - epublish
SO  - Front Neural Circuits. 2014 Sep 18;8:117. doi: 10.3389/fncir.2014.00117. 
      eCollection 2014.