PMID- 25278984
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141003
LR  - 20211021
IS  - 1738-5520 (Print)
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 44
IP  - 5
DP  - 2014 Sep
TI  - Late gadolinium enhancement in cardiac MRI in patients with severe aortic 
      stenosis and preserved left ventricular systolic function is related to 
      attenuated improvement of left ventricular geometry and filling pressure after 
      aortic valve replacement.
PG  - 312-9
LID - 10.4070/kcj.2014.44.5.312 [doi]
AB  - BACKGROUND AND OBJECTIVES: WE INVESTIGATED ECHOCARDIOGRAPHIC PREDICTORS: left 
      ventricular (LV) geometric changes following aortic valve replacement (AVR) 
      according to the late gadolinium enhancement (LGE) on cardiac magnetic resonance 
      imaging (CMR) in patients with severe aortic stenosis (AS) and preserved LV 
      systolic function. SUBJECTS AND METHODS: We analyzed 41 patients (24 males, 
      63.1+/-8.7 years) with preserved LV systolic function who were scheduled to undergo 
      AVR for severe AS. All patients were examined with transthoracic echocardiography 
      (TTE), CMR before and after AVR (in the hospital) and serial TTEs (at 6 and 12 
      months) were repeated. RESULTS: The group with LGE (LGE+) showed greater wall 
      thickness (septum, 14.3+/-2.6 mm vs. 11.5+/-2.0 mm, p=0.001, posterior; 14.3+/-2.5 mm 
      vs. 11.4+/-1.6 mm, p<0.001), lower tissue Doppler image (TDIS', 4.4+/-1.4 cm/s vs. 
      5.5+/-1.2 cm/s, p=0.021; TDI E', 3.2+/-0.9 cm/s vs. 4.8+/-1.4 cm/s, p=0.002), and 
      greater E/e' (21.8+/-10.3 vs. 15.4+/-6.3, p=0.066) than those without LGE (LGE-). 
      Multivariate analysis show that TDI e' (odds ratio=0.078, 95% confidence 
      interval=0.007-0.888, p=0.040) was an independent determinant of LGE+. In an 
      analysis of the 6- and 12-month follow-up compared with pre-AVR, LGE- showed 
      decreased LV end-diastolic diameter (48.3+/-5.0 mm vs. 45.8+/-3.6 mm, p=0.027; 
      48.3+/-5.0 mm vs. 46.5+/-3.4 mm, p=0.019). Moreover, E/e' (at 12 months) showed 
      further improved LV filling pressure (16.0+/-6.6 vs. 12.3+/-4.3, p=0.001) compared 
      with pre-AVR. However, LGE+ showed no significant improvement. CONCLUSION: The 
      absence of LGE is associated with favorable improvements in LV geometry and 
      filling pressure. TDI E' is an independent determinant of LGE in patients with 
      severe AS and preserved LV systolic function.
FAU - Park, Junbeom
AU  - Park J
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Chang, Hyuk-Jae
AU  - Chang HJ
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea. ; Severance Biomedical Science Institute, 
      Yonsei University College of Medicine, Yonsei University Health System, Seoul, 
      Korea.
FAU - Choi, Jung-Ho
AU  - Choi JH
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Yang, Pil-Sung
AU  - Yang PS
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Lee, Sang-Eun
AU  - Lee SE
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Heo, Ran
AU  - Heo R
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Shin, Sanghoon
AU  - Shin S
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Cho, In-Jeong
AU  - Cho IJ
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Kim, Young-Jin
AU  - Kim YJ
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Shim, Chi Young
AU  - Shim CY
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Hong, Geu-Ru
AU  - Hong GR
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
FAU - Chung, Namsik
AU  - Chung N
AD  - Division of Cardiology and Radiology, Severance Cardiovascular Hospital, Yonsei 
      University Health System, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140925
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC4180608
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Cardiac magnetic resonance imaging
OT  - Echocardiography
OT  - Late gadolinium enhancement
COIS- The authors have no financial conflicts of interest.
EDAT- 2014/10/04 06:00
MHDA- 2014/10/04 06:01
PMCR- 2014/09/01
CRDT- 2014/10/04 06:00
PHST- 2014/02/27 00:00 [received]
PHST- 2014/05/27 00:00 [revised]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2014/10/04 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.4070/kcj.2014.44.5.312 [doi]
PST - ppublish
SO  - Korean Circ J. 2014 Sep;44(5):312-9. doi: 10.4070/kcj.2014.44.5.312. Epub 2014 
      Sep 25.