PMID- 25279150
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 2
IP  - 6
DP  - 2014 Nov
TI  - Induction of HLA-A*33-restricted cytotoxic lymphocytes against renal cell 
      carcinoma targeting galectin 9 and PINCH.
PG  - 809-812
AB  - Galectin 9, a ligand of T cell immunoglobulin and mucin domain 3 (TIM-3), and 
      PINCH, an epithelial-to-mesenchymal transition (EMT)-promoting molecule, are 
      expressed at much higher levels in cancerous lesions of clear cell type renal 
      cell carcinoma (RCC) compared to normal renal tissues, and their expression 
      levels are extremely low in normal tissues, except for galectin 9 in the spleen. 
      Galectin 9- and PINCH-derived peptides have previously been shown to induce human 
      leukocyte antigen (HLA)-A*2402-restricted and HLA-A*0201-restricted cytotoxic 
      lymphocytes (CTLs) with specific and highly cytotoxic activities toward RCC 
      cells. The present study aimed to identify the peptides that induced 
      HLA-A*33-restricted CTLs that exhibited specific and highly cytotoxic activities 
      toward RCC cells. Specific CTLs were induced significantly, as shown by cluster 
      of differentiation 107a degranulation stimulated with VMRC-RCW renal carcinoma 
      cells. Therefore, peptide vaccines targeting galectin 9 and PINCH appear to be 
      promising for clinical application.
FAU - Kawashima, Hidenori
AU  - Kawashima H
AD  - Shirahama Hamayu Hospital, Shirahama, Wakayama 649-2211, Japan ; Department of 
      Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, 
      Japan.
FAU - Masaki, Sakae
AU  - Masaki S
AD  - Department of Urology, Osaka City University Graduate School of Medicine, Osaka 
      545-8585, Japan.
FAU - Kawamura, Marie
AU  - Kawamura M
AD  - Department of Urology, Osaka City University Graduate School of Medicine, Osaka 
      545-8585, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140808
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC4179774
OTO - NOTNLM
OT  - PINCH
OT  - cytotoxic T lymphocytes
OT  - epithelial-to-mesenchymal transition
OT  - galectin 9
OT  - immune checkpoints
OT  - renal cell carcinoma
EDAT- 2014/10/04 06:00
MHDA- 2014/10/04 06:01
PMCR- 2014/08/08
CRDT- 2014/10/04 06:00
PHST- 2014/07/10 00:00 [received]
PHST- 2014/08/01 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2014/10/04 06:01 [medline]
PHST- 2014/08/08 00:00 [pmc-release]
AID - br-02-06-0809 [pii]
AID - 10.3892/br.2014.334 [doi]
PST - ppublish
SO  - Biomed Rep. 2014 Nov;2(6):809-812. doi: 10.3892/br.2014.334. Epub 2014 Aug 8.