PMID- 25279812
OWN - NLM
STAT- MEDLINE
DCOM- 20151221
LR  - 20150218
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 82
IP  - 3
DP  - 2015 Mar
TI  - Breast cancer risk in MEN1 - a cancer genetics perspective.
PG  - 327-229
LID - 10.1111/cen.12614 [doi]
AB  - The tumour spectrum associated with multiple endocrine neoplasia type 1 (MEN1) 
      has been known for many years. New data suggest that females with MEN1 may face 
      an additional, hitherto unrecognized, risk of early-onset breast cancer. The 
      menin protein is certainly known to have a role in regulating oestrogen receptor 
      activity; but how robust are the data linking MEN1 to breast cancer? This article 
      examines the published data from the viewpoint of a cancer geneticist and 
      considers whether there really is a justifiable indication for enhanced breast 
      surveillance in women with MEN1.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Brennan, Paul
AU  - Brennan P
AD  - Northern Genetics Service, Newcastle Upon Tyne, UK.
LA  - eng
PT  - Journal Article
DEP - 20141105
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
CIN - Clin Endocrinol (Oxf). 2015 Jul;83(1):141. PMID: 25409873
MH  - Breast Neoplasms/*epidemiology/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Mutation
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Risk Factors
EDAT- 2014/10/04 06:00
MHDA- 2015/12/22 06:00
CRDT- 2014/10/04 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2014/09/07 00:00 [revised]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/15 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2015/12/22 06:00 [medline]
AID - 10.1111/cen.12614 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2015 Mar;82(3):327-229. doi: 10.1111/cen.12614. Epub 2014 
      Nov 5.