PMID- 25280709
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20151119
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 44
DP  - 2014 Nov
TI  - Magnetic glass ceramics for sustained 5-fluorouracil delivery: characterization 
      and evaluation of drug release kinetics.
PG  - 293-309
LID - S0928-4931(14)00507-4 [pii]
LID - 10.1016/j.msec.2014.08.022 [doi]
AB  - In the present study, magnetic glass ceramics in the system Fe2O3 ∙ TiO2 ∙ P2O5 ∙ 
      SiO2 ∙ MO (M=Mg, Ca, Mn, Cu, Zn or Ce) are prepared. The effect of adding 
      different cations on the thermal behavior, developed phases, microstructure and 
      magnetic properties is studied using differental thermal analysis (DTA), X-ray 
      diffraction analysis (XRD), transmission electron microscope (TEM), FT-infrared 
      transmission (FT-IR) and vibrating sample magnetometer (VSM) respectively. The 
      magnetic glass ceramics are tested as delivery systems for 5-fluorouracil. 
      Modeling and analysis of release kinetics are addressed. The application of 
      Higuchi square root of time model and the first order release model indicated 
      that, 5-FU is released by diffusion controlled mechanisms, and that its released 
      rate depends greatly on the concentration of loaded drug during the loading 
      stage. The obtained results suggested that, the prepared magnetic glass ceramics 
      can be used for cancer treatment by hyperthermia and/or by localized delivery of 
      therapeutic doses of 5-fluorouracil.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Abdel-Hameed, S A M
AU  - Abdel-Hameed SA
AD  - Glass Research Department, National Research Center, Dokki, ElBehoos St., Cairo 
      12311, Egypt. Electronic address: Salwa_NRC@hotmail.com.
FAU - El-Kady, A M
AU  - El-Kady AM
AD  - Biomaterial Department, National Research Center, Dokki, ElBehoos St., Cairo 
      12311, Egypt.
FAU - Marzouk, M A
AU  - Marzouk MA
AD  - Glass Research Department, National Research Center, Dokki, ElBehoos St., Cairo 
      12311, Egypt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140812
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ferric Compounds)
RN  - 0 (Phosphorus Compounds)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 1K09F3G675 (ferric oxide)
RN  - 51SWB7223J (phosphorus pentoxide)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 85422-94-2 (Glass ceramics)
RN  - D1JT611TNE (Titanium)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Biocompatible Materials
MH  - Ceramics/*chemistry
MH  - Crystallization
MH  - Drug Delivery Systems/*methods
MH  - *Drug Liberation
MH  - Ferric Compounds/chemistry
MH  - Fluorouracil/*chemistry/pharmacology
MH  - Hydrogen-Ion Concentration
MH  - *Magnetics
MH  - Microscopy, Electron, Transmission
MH  - Phosphorus Compounds/chemistry
MH  - Silicon Dioxide/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Titanium/chemistry
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - 5-Fluorouracil
OT  - Drug delivery
OT  - Glass ceramics
OT  - Magnetic
EDAT- 2014/10/05 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/10/05 06:00
PHST- 2014/04/08 00:00 [received]
PHST- 2014/06/25 00:00 [revised]
PHST- 2014/08/05 00:00 [accepted]
PHST- 2014/10/05 06:00 [entrez]
PHST- 2014/10/05 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
AID - S0928-4931(14)00507-4 [pii]
AID - 10.1016/j.msec.2014.08.022 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:293-309. doi: 
      10.1016/j.msec.2014.08.022. Epub 2014 Aug 12.