PMID- 25280747 OWN - NLM STAT- MEDLINE DCOM- 20160517 LR - 20220316 IS - 1434-4726 (Electronic) IS - 0937-4477 (Linking) VI - 272 IP - 11 DP - 2015 Nov TI - Elderly patients at higher risk of laryngeal carcinoma recurrence could be identified by a panel of two biomarkers (nm23-H1 and CD105) and pN+ status. PG - 3417-24 LID - 10.1007/s00405-014-3310-1 [doi] AB - Laryngeal squamous cell carcinoma (LSCC) recurrences are very difficult to manage in elderly patients (age >/=65 years), because treatment carries significant morbidity and mortality. The aim of this study was to develop a panel of parameters (clinicopathological variables or biomarkers) to improve our ability to detect elderly patients at higher risk of LSCC recurrence. Maspin, nm23-H1, and CD105 were investigated using immunohistochemistry on surgical specimens from 46 elderly patients treated for LSCC. After univariate analysis identified parameters associated with LSCC recurrence, a multivariate prognostic model was constructed. At univariate analysis, a higher recurrence rate was significantly associated with nm23-H1 nuclear expression in carcinoma cells /=5.28% (p = 0.04), and pN+ status (p = 0.04). Multivariate modeling confirmed that nuclear nm23-H1 /=5.28% (p = 0.013) had a negative prognostic significance in terms of disease recurrence, while pN+ status showed a trend toward significance (p = 0.05). We thus obtained a panel comprising two biomarkers and neck lymph node status that revealed an excellent discriminatory power [AUC (ROC) of 0.81] in terms of the risk of LSCC recurrence. The panel achieved a specificity of 96% and a positive predictive value of 93%. We identified a panel with an excellent discriminatory power in identifying elderly patients at higher risk of recurrence after treatment for LSCC. These patients would benefit from a more aggressive primary treatment. FAU - Lovato, Andrea AU - Lovato A AD - Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy. FAU - Marioni, Gino AU - Marioni G AD - Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy. gino.marioni@unipd.it. FAU - Manzato, Enzo AU - Manzato E AD - Department of Medicine DIMED, University of Padova, Padua, Italy. FAU - Staffieri, Claudia AU - Staffieri C AD - Otolaryngology Section, Department of Neurosciences, Treviso Hospital Branch, University of Padova, Padua, Italy. FAU - Giacomelli, Luciano AU - Giacomelli L AD - Department of Medicine DIMED, University of Padova, Padua, Italy. FAU - Ralli, Giovanni AU - Ralli G AD - ENT Department, University of Rome "La Sapienza", Rome, Italy. FAU - Staffieri, Alberto AU - Staffieri A AD - Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy. FAU - Blandamura, Stella AU - Blandamura S AD - Department of Medicine DIMED, University of Padova, Padua, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141004 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 RN - 0 (Antigens, CD) RN - 0 (Biomarkers, Tumor) RN - 0 (ENG protein, human) RN - 0 (Endoglin) RN - 0 (NM23 Nucleoside Diphosphate Kinases) RN - 0 (Receptors, Cell Surface) RN - EC 2.7.4.6 (NME1 protein, human) SB - IM MH - Aged MH - Aged, 80 and over MH - Antigens, CD/*metabolism MH - Biomarkers, Tumor/metabolism MH - Carcinoma, Squamous Cell/*metabolism/pathology MH - Endoglin MH - Endothelial Cells/metabolism MH - Female MH - Humans MH - Laryngeal Neoplasms/*metabolism/pathology MH - Male MH - NM23 Nucleoside Diphosphate Kinases/*metabolism MH - Neoplasm Recurrence, Local/*metabolism MH - Receptors, Cell Surface/*metabolism OTO - NOTNLM OT - Biomarkers OT - Elderly OT - Laryngeal carcinoma OT - Panel OT - Prognosis EDAT- 2014/10/05 06:00 MHDA- 2016/05/18 06:00 CRDT- 2014/10/05 06:00 PHST- 2014/08/18 00:00 [received] PHST- 2014/09/23 00:00 [accepted] PHST- 2014/10/05 06:00 [entrez] PHST- 2014/10/05 06:00 [pubmed] PHST- 2016/05/18 06:00 [medline] AID - 10.1007/s00405-014-3310-1 [pii] AID - 10.1007/s00405-014-3310-1 [doi] PST - ppublish SO - Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3417-24. doi: 10.1007/s00405-014-3310-1. Epub 2014 Oct 4.