PMID- 25281206
OWN - NLM
STAT- MEDLINE
DCOM- 20150722
LR  - 20150831
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 28
DP  - 2014 Dec
TI  - Impacts of human leukocyte antigen DQ genetic polymorphisms and their 
      interactions with hepatitis B virus mutations on the risks of viral persistence, 
      liver cirrhosis, and hepatocellular carcinoma.
PG  - 201-9
LID - S1567-1348(14)00366-9 [pii]
LID - 10.1016/j.meegid.2014.09.032 [doi]
AB  - Human leukocyte antigen (HLA)-DQ genetic polymorphisms have been associated with 
      chronic hepatitis B virus (HBV) outcomes. We aimed to determine impacts of HLA-DQ 
      polymorphisms and their interactions with HBV mutations on the risks of liver 
      cirrhosis (LC) and hepatocellular carcinoma (HCC). rs2856718 (A>G) and rs9275319 
      (A>G) were genotyped in 1342 healthy controls, 327 HBV surface antigen (HBsAg) 
      seroclearance subjects, 611 asymptomatic HBsAg carriers (ASCs), 1144 chronic 
      hepatitis B (CHB) patients, 734 LC patients, and 1531 HCC patients using 
      quantitative PCR. HBV mutations were detected by direct sequencing. Logistic 
      regression analyses were utilized to assess the factors and/or multiplicative 
      interactions significantly associated with liver diseases. rs9275319 variant 
      genotypes were inversely associated with HBV persistence compared to HBV natural 
      clearance subjects. rs2856718 variant genotypes significantly increased LC risk 
      compared to ASCs plus CHB patients (GG vs. AA: odds ratio [OR], 1.52, 95% 
      confidence interval [CI], 1.17-1.97 and AG+GG vs. AA: OR, 1.27; 95% CI, 
      1.04-1.54) and decreased HCC risk compared to HCC-free HBV-infected subjects (AG 
      vs. AA: OR, 0.76; 95% CI, 0.65-0.89 and AG+GG vs. AA: OR, 0.78, 95% CI, 
      0.68-0.90). rs2856718 variant genotypes were significantly associated with an 
      increased frequency of HBV A1726C mutation, a LC-risk, HCC-protective mutation, 
      in genotype C. A rs9275319 variant genotype (GG) was significantly associated 
      with an increased frequency of preS1 start codon mutation, an HCC-risk mutation, 
      in genotype C. The interaction of rs2856718 AG+GG genotype with T1753V, a 
      HCC-risk mutation, significantly reduced LC risk, with an OR of 0.26 (95% CI, 
      0.09-0.78); whereas the interaction of rs2856718 AG genotype with C1673T, a 
      LC-risk mutation, significantly increased HCC risk, with an OR of 2.80 (95% CI, 
      1.02-7.66) in genotype C HBV-infected subjects. Conclusively, the HLA-DQ 
      polymorphisms affect the risks of LC and HCC differently in chronic HBV-infected 
      subjects, possibly via interacting with the HBV mutations.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Ji, Xiaowei
AU  - Ji X
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Li, Bin
AU  - Li B
AD  - Biliary Tract Surgery Department I, Eastern Hepatobiliary Surgery Hospital, 
      Secondary Military Medical University, 225 Changhai Road, Shanghai, China.
FAU - Du, Yan
AU  - Du Y
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Yin, Jianhua
AU  - Yin J
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Liu, Wenbin
AU  - Liu W
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Zhang, Hongwei
AU  - Zhang H
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China.
FAU - Cao, Guangwen
AU  - Cao G
AD  - Department of Epidemiology, Second Military Medical University, 800 Xiangyin 
      Road, Shanghai, China. Electronic address: gcao@smmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141002
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adult
MH  - Carcinoma, Hepatocellular/*genetics/immunology/virology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - Hepatitis B Surface Antigens/*genetics
MH  - Hepatitis B virus/*genetics/immunology
MH  - Hepatitis B, Chronic/*genetics/immunology/virology
MH  - Humans
MH  - Liver Cirrhosis/*genetics/immunology/virology
MH  - Liver Neoplasms/*genetics/immunology/virology
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - HLA-DQ
OT  - Hepatitis B virus
OT  - Hepatocellular carcinoma
OT  - Liver cirrhosis
OT  - Mutations
OT  - Single nucleotide polymorphism
EDAT- 2014/10/05 06:00
MHDA- 2015/07/23 06:00
CRDT- 2014/10/05 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2014/09/21 00:00 [revised]
PHST- 2014/09/25 00:00 [accepted]
PHST- 2014/10/05 06:00 [entrez]
PHST- 2014/10/05 06:00 [pubmed]
PHST- 2015/07/23 06:00 [medline]
AID - S1567-1348(14)00366-9 [pii]
AID - 10.1016/j.meegid.2014.09.032 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2014 Dec;28:201-9. doi: 10.1016/j.meegid.2014.09.032. Epub 
      2014 Oct 2.