PMID- 25281791
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20141216
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 584
DP  - 2015 Jan 1
TI  - TIMP1 in conditioned media of human adipose stromal cells protects neurons 
      against oxygen-glucose deprivation injury.
PG  - 56-9
LID - S0304-3940(14)00793-9 [pii]
LID - 10.1016/j.neulet.2014.09.045 [doi]
AB  - Adipose stromal cells (ASC) can protect neurons when administered to brains due 
      to secreted trophic factors. Our previous studies demonstrated that several 
      neurotrophic factors such as brain-derived neurotropic factor (BDNF) and insulin 
      like growth factor-1 (IGF-1) in ASC conditioned media (ASC-CM) can protect brains 
      against hypoxic-ischemic (HI) injury in neonatal rats. In this study, we 
      demonstrated that human ASC-CM potently blockeds caspase-3 mediated cortical 
      neuronal apoptosis under in vitro oxygen-glucose deprivation (OGD). 
      Interestingly, tissue inhibitor of metalloproteinase 1 (TIMP1), a non 
      neurotrophic factor, played a significant role in the ASC-CM-induced neural 
      protection against OGD. Thus, this study establishes the therapeutic potential of 
      TIMP1 together with other neurotrophic factors in ASC-CM for treating cerebral HI 
      disorders.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Du, Shiwei
AU  - Du S
AD  - General Hospital of the Chinese People's Armed Police Forces, Beijing, PR China.
FAU - Mao, Gengsheng
AU  - Mao G
AD  - General Hospital of the Chinese People's Armed Police Forces, Beijing, PR China. 
      Electronic address: neurology@163.com.
FAU - Zhu, Timothy
AU  - Zhu T
AD  - Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN 
      46202, United States.
FAU - Luan, Zuo
AU  - Luan Z
AD  - Department of Pediatrics, Navy General Hospital, No. 6 Fucheng Road, Beijing, PR 
      China.
FAU - Du, Yansheng
AU  - Du Y
AD  - Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN 
      46202, United States.
FAU - Gu, Huiying
AU  - Gu H
AD  - Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN 
      46202, United States. Electronic address: huiygu@iupui.edu.
LA  - eng
PT  - Journal Article
DEP - 20141002
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.22.- (Caspase 3)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adipose Tissue/cytology/*metabolism
MH  - Animals
MH  - Apoptosis
MH  - Caspase 3/metabolism
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology
MH  - Culture Media, Conditioned
MH  - Enzyme Activation
MH  - Glucose/*metabolism
MH  - Humans
MH  - Neurons/*cytology
MH  - Oxygen/*metabolism
MH  - Rats, Sprague-Dawley
MH  - Stromal Cells/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/*metabolism
OTO - NOTNLM
OT  - Adipose stromal cells
OT  - Oxygen-glucose deprivation
OT  - TIMP1
EDAT- 2014/10/05 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/10/05 06:00
PHST- 2014/07/31 00:00 [received]
PHST- 2014/09/22 00:00 [revised]
PHST- 2014/09/24 00:00 [accepted]
PHST- 2014/10/05 06:00 [entrez]
PHST- 2014/10/05 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - S0304-3940(14)00793-9 [pii]
AID - 10.1016/j.neulet.2014.09.045 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jan 1;584:56-9. doi: 10.1016/j.neulet.2014.09.045. Epub 2014 
      Oct 2.