PMID- 25282282
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20151119
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 60
DP  - 2015 Jan
TI  - Decreased cortical thickness in drug naive first episode schizophrenia: in 
      relation to serum levels of BDNF.
PG  - 22-8
LID - S0022-3956(14)00276-3 [pii]
LID - 10.1016/j.jpsychires.2014.09.009 [doi]
AB  - This study was to examine cortical thickness in drug naive, first episode 
      schizophrenia patients, and to explore its relationship with serum levels of 
      brain-derived neurotrophic factor (BDNF). Forty-five drug naive schizophrenia 
      patients and 28 healthy controls were enrolled in the study. Freesurfer was used 
      to parcellate cortical regions, and vertex-wise group analysis was used for whole 
      brain cortical thickness. The clusters for the brain regions that demonstrated 
      group differences were extracted, and the mean values of thickness were 
      calculated. Serum levels of BDNF were measured using enzyme-linked immunosorbent 
      assay (ELISA). After controlling for age and gender, significantly thinner 
      cortical thickness was found in left insula and superior temporal gyrus in the 
      patient group compared with the healthy control group (HC group) (p's < 0.001). 
      Lower serum levels of BDNF were also found in the patient group compared with the 
      HC group (p = 0.001). Correlation analysis showed a significant positive 
      relationship between thickness of left insula and serum levels of BDNF within the 
      HC group (r = 0.396, p = 0.037) but there was no such relationship within the 
      patient group (r = 0.035, p = 0.819). Cortical thinning is present in drug naive, 
      first episode schizophrenia patients, indicating neurodevelopmental abnormalities 
      at the onset of schizophrenia. Left insula might be an imaging biomarker in 
      detecting the impaired protective role of neurotrophic factor for the brain 
      development in schizophrenia.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Song, Xueqin
AU  - Song X
AD  - The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. Electronic 
      address: sxqzhll@126.com.
FAU - Quan, Meina
AU  - Quan M
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA.
FAU - Lv, Luxian
AU  - Lv L
AD  - Henan Province Biological Psychiatry Key Laboratory, Xinxiang Medical University, 
      Xinxiang, China; Henan Province Mental Hospital, The Second Affiliated Hospital, 
      Xinxiang Medical University, Xinxiang, China.
FAU - Li, Xue
AU  - Li X
AD  - The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
FAU - Pang, Lijuan
AU  - Pang L
AD  - The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
FAU - Kennedy, David
AU  - Kennedy D
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA.
FAU - Hodge, Steven
AU  - Hodge S
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA.
FAU - Harrington, Amy
AU  - Harrington A
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA.
FAU - Ziedonis, Douglas
AU  - Ziedonis D
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA.
FAU - Fan, Xiaoduo
AU  - Fan X
AD  - UMass Memorial Medical Center, University of Massachusetts Medical School, 
      Worcester, MA, USA. Electronic address: Xiaoduo.fan@umassmed.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140919
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebral Cortex/*pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Cortical thickness
OT  - First episode schizophrenia
EDAT- 2014/10/06 06:00
MHDA- 2015/08/05 06:00
CRDT- 2014/10/06 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2014/08/16 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/10/06 06:00 [entrez]
PHST- 2014/10/06 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
AID - S0022-3956(14)00276-3 [pii]
AID - 10.1016/j.jpsychires.2014.09.009 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2015 Jan;60:22-8. doi: 10.1016/j.jpsychires.2014.09.009. Epub 
      2014 Sep 19.