PMID- 25284321
OWN - NLM
STAT- MEDLINE
DCOM- 20151223
LR  - 20211021
IS  - 1724-191X (Electronic)
IS  - 1120-1797 (Print)
IS  - 1120-1797 (Linking)
VI  - 31
IP  - 1
DP  - 2015 Feb
TI  - Volumetric-modulated arc therapy for oropharyngeal carcinoma: a dosimetric and 
      delivery efficiency comparison with static-field IMRT.
PG  - 54-9
LID - S1120-1797(14)00526-2 [pii]
LID - 10.1016/j.ejmp.2014.09.003 [doi]
AB  - The purpose of this study is to evaluate the treatment plan adequacy and delivery 
      efficiency among volumetric-modulated arc therapy (VMAT) with one or two arcs and 
      the conventional static-field dynamic multileaf collimator (dMLC) 
      intensity-modulated radiation therapy (IMRT) in patients undergoing oropharyngeal 
      carcinoma. Fifteen patient cases were included in this investigation. Each of the 
      cases was planned using step-and-shoot IMRT, VMAT with a single arc (Arc1) and 
      VMAT with double arcs (Arc2). A two-dose level prescription for planning target 
      volumes (PTVs) was delivered with 70 Gy/56 Gy in 30 fractions. Comparisons were 
      performed of the dose-volume histograms (DVH) for PTVs, the DVH for organs at 
      risk (OARs), the monitor units per fraction (MU/fx), and delivery time. IMRT and 
      Arc2 achieved similar target coverage, but superior to Arc1. Apart from the oral 
      cavity, Arc1 showed no advantage in sparing of OARs compared with IMRT, while 
      Arc2 obtained equivalent or better sparing of OARs among the three techniques. 
      VMAT reduced MU/fx and shortened delivery time remarkably compared with IMRT. Our 
      results demonstrated that for oropharyngeal cases, Arc2 can achieve superior 
      target coverage and normal tissue sparing, as well as a significant reduction in 
      treatment time.
CI  - Copyright (c) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Dai, Xiaofang
AU  - Dai X
AD  - Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, 
      Wuhan, China.
FAU - Zhao, Yingchao
AU  - Zhao Y
AD  - Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, 
      Wuhan, China.
FAU - Liang, Zhiwen
AU  - Liang Z
AD  - Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, 
      Wuhan, China.
FAU - Dassarath, Meera
AU  - Dassarath M
AD  - Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, 
      Wuhan, China.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Jin, Lihui
AU  - Jin L
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Chen, Lili
AU  - Chen L
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Dong, James
AU  - Dong J
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Price, Robert A
AU  - Price RA
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA.
FAU - Ma, C-M
AU  - Ma CM
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 
      19111, USA. Electronic address: Charlie.ma@fccc.edu.
LA  - eng
GR  - P30 CA006927/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141003
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
SB  - IM
MH  - Carcinoma, Squamous Cell/radiotherapy
MH  - Humans
MH  - Organs at Risk/radiation effects
MH  - Oropharyngeal Neoplasms/*radiotherapy
MH  - Radiometry
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*methods
MH  - Time Factors
PMC - PMC4282814
MID - NIHMS632265
OTO - NOTNLM
OT  - IMRT
OT  - Intensity-modulated radiation therapy
OT  - Oropharyngeal carcinoma
OT  - Radiotherapy
OT  - VMAT
OT  - Volumetric-modulated arc therapy
EDAT- 2014/10/07 06:00
MHDA- 2015/12/24 06:00
PMCR- 2016/02/01
CRDT- 2014/10/07 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/09/04 00:00 [revised]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2014/10/07 06:00 [entrez]
PHST- 2014/10/07 06:00 [pubmed]
PHST- 2015/12/24 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - S1120-1797(14)00526-2 [pii]
AID - 10.1016/j.ejmp.2014.09.003 [doi]
PST - ppublish
SO  - Phys Med. 2015 Feb;31(1):54-9. doi: 10.1016/j.ejmp.2014.09.003. Epub 2014 Oct 3.