PMID- 25284351
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 1
DP  - 2015 Aug
TI  - Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF 
      Expression in Experimental Pneumococcal Meningitis.
PG  - 734-40
LID - 10.1007/s12035-014-8914-3 [doi]
AB  - Pneumococcal meningitis is a serious infection of the central nervous system 
      (CNS) with high fatality rates that causes reduced psychomotor performance, 
      slight mental slowness, impairments in attention executive functions and learning 
      and memory deficiencies. Previously, we demonstrated a correlation between memory 
      impairment and decreased levels of brain-derived neurotropic factor (BDNF) in the 
      hippocampi of rats subjected to pneumococcal meningitis. Emerging evidence 
      demonstrates that histone acetylation regulates neurotrophins; therefore, a 
      potential molecular intervention against cognitive impairment in bacterial 
      meningitis may be the histone deacetylase (HDAC) inhibitor, sodium butyrate, 
      which stimulates the acetylation of histones and increases BDNF expression. In 
      this study, animals received either artificial cerebrospinal fluid as a placebo 
      or a Streptococcus pneumoniae suspension at a concentration of 5 x 10(9) 
      colony-forming units (CFU/mL). The animals received antibiotic treatment as usual 
      and received saline or sodium butyrate as an adjuvant treatment. Ten days after, 
      meningitis was induced; the animals were subjected to open-field habituation and 
      the step-down inhibitory avoidance task. Immediately after these behavioural 
      tasks, the animals were killed, and their hippocampi were removed to evaluate the 
      expression of BDNF, nerve growth factor (NGF) and glial cell line-derived 
      neurotrophic factor (GDNF). In the meningitis group that received saline, the 
      animals presented memory impairment in both behavioural tasks, and hippocampal 
      BDNF and GDNF expression was decreased. Sodium butyrate was able to prevent 
      memory impairment and re-establish hippocampal neurotrophin expression in 
      experimental pneumococcal meningitis.
FAU - Barichello, Tatiana
AU  - Barichello T
AD  - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, 
      Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, 
      Brazil, tba@unesc.net.
FAU - Generoso, Jaqueline S
AU  - Generoso JS
FAU - Simoes, Lutiana R
AU  - Simoes LR
FAU - Faller, Cristiano Julio
AU  - Faller CJ
FAU - Ceretta, Renan A
AU  - Ceretta RA
FAU - Petronilho, Fabricia
AU  - Petronilho F
FAU - Lopes-Borges, Jessica
AU  - Lopes-Borges J
FAU - Valvassori, Samira S
AU  - Valvassori SS
FAU - Quevedo, Joao
AU  - Quevedo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141005
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 107-92-6 (Butyric Acid)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Butyric Acid/pharmacology/*therapeutic use
MH  - Glial Cell Line-Derived Neurotrophic Factor/*metabolism
MH  - Habituation, Psychophysiologic
MH  - Male
MH  - Memory Disorders/complications/*drug therapy/*prevention & control
MH  - Meningitis, Pneumococcal/*complications/*drug therapy
MH  - Nerve Growth Factor/metabolism
MH  - Rats, Wistar
EDAT- 2014/10/07 06:00
MHDA- 2016/05/18 06:00
CRDT- 2014/10/07 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/09/28 00:00 [accepted]
PHST- 2014/10/07 06:00 [entrez]
PHST- 2014/10/07 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - 10.1007/s12035-014-8914-3 [pii]
AID - 10.1007/s12035-014-8914-3 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Aug;52(1):734-40. doi: 10.1007/s12035-014-8914-3. Epub 2014 
      Oct 5.