PMID- 25286027
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Associations between the duration of dialysis, endotoxemia, monocyte 
      chemoattractant protein-1, and the effects of a short-dwell exchange in patients 
      requiring continuous ambulatory peritoneal dialysis.
PG  - e109558
LID - 10.1371/journal.pone.0109558 [doi]
LID - e109558
AB  - BACKGROUND: Endotoxemia is exaggerated and contributes to systemic inflammation 
      and atherosclerosis in patients requiring continuous ambulatory peritoneal 
      dialysis (CAPD). The risk of mortality is substantially increased in patients 
      requiring CAPD for >2 years. However, little is known about the effects of 
      long-term CAPD on circulating endotoxin and cytokine levels. Therefore, the 
      present study evaluated the associations between plasma endotoxin levels, 
      cytokine levels, and clinical parameters with the effects of a short-dwell 
      exchange on endotoxemia and cytokine levels in patients on long-term CAPD. 
      METHODS: A total of 26 patients were enrolled and divided into two groups 
      (short-term or long-term CAPD) according to the 2-year duration of CAPD. Plasma 
      endotoxin and cytokine levels were measured before and after a short-dwell 
      exchange (4-h dwell) during a peritoneal equilibration test (a standardized 
      method to evaluate the solute transport function of peritoneal membrane). These 
      data were analyzed to determine the relationship of circulating endotoxemia, 
      cytokines and clinical characteristics between the two groups. RESULTS: Plasma 
      endotoxin and monocyte chemotactic protein-1 (MCP-1) levels were significantly 
      elevated in the long-term group. PD duration was significantly correlated with 
      plasma endotoxin (r = 0.479, P = 0.016) and MCP-1 (r = 0.486, P = 0.012). PD 
      duration was also independently associated with plasma MCP-1 levels in 
      multivariate regression. Plasma MCP-1 levels tended to decrease (13.3% reduction, 
      P = 0.077) though endotoxin levels did not decrease in the long-term PD group 
      after the 4-h short-dwell exchange. CONCLUSION: Long-term PD may result in 
      exaggerated endotoxemia and elevated plasma MCP-1 levels. The duration of PD was 
      significantly correlated with circulating endotoxin and MCP-1 levels, and was an 
      independent predictor of plasma MCP-1 levels. Short-dwell exchange seemed to have 
      favorable effects on circulating MCP-1 levels in patients on long-term PD.
FAU - Wu, Chia-Lin
AU  - Wu CL
AD  - Division of Nephrology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan; School of Medicine, Chung-Shan Medical University, 
      Taichung, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, 
      Taipei, Taiwan.
FAU - Wu, Hung-Ming
AU  - Wu HM
AD  - Inflammation Research and Drug Development Center, Changhua Christian Hospital, 
      Changhua, Taiwan.
FAU - Chiu, Ping-Fang
AU  - Chiu PF
AD  - Division of Nephrology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan; School of Medicine, Chung-Shan Medical University, 
      Taichung, Taiwan.
FAU - Liou, Hung-Hsiang
AU  - Liou HH
AD  - Division of Nephrology, Department of Internal Medicine, Hsin Jen Hospital, 
      Taipei, Taiwan.
FAU - Chang, Chirn-Bin
AU  - Chang CB
AD  - Division of Nephrology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan; School of Medicine, Chung-Shan Medical University, 
      Taichung, Taiwan.
FAU - Tarng, Der-Cherng
AU  - Tarng DC
AD  - Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; 
      Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, 
      Taipei, Taiwan; Department and Institute of Physiology, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Chang, Chia-Chu
AU  - Chang CC
AD  - Division of Nephrology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan; School of Medicine, Chung-Shan Medical University, 
      Taichung, Taiwan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141006
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Chemokine CCL2)
RN  - 0 (Endotoxins)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Endotoxemia/*blood/complications
MH  - Endotoxins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peritoneal Dialysis, Continuous Ambulatory/*methods
MH  - Time Factors
MH  - Young Adult
PMC - PMC4186838
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/07 06:00
MHDA- 2015/12/17 06:00
PMCR- 2014/10/06
CRDT- 2014/10/07 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/10/07 06:00 [entrez]
PHST- 2014/10/07 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
PHST- 2014/10/06 00:00 [pmc-release]
AID - PONE-D-14-31771 [pii]
AID - 10.1371/journal.pone.0109558 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 6;9(10):e109558. doi: 10.1371/journal.pone.0109558. 
      eCollection 2014.