PMID- 25286334
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20150724
IS  - 1743-5404 (Electronic)
IS  - 1743-5390 (Linking)
VI  - 9
IP  - 5
DP  - 2015
TI  - Perspectives on percutaneous penetration: Silica nanoparticles.
PG  - 643-57
LID - 10.3109/17435390.2014.958115 [doi]
AB  - Nanotechnology is a rapidly expanding area of research involved in developing 
      science-based solutions for innovative therapeutics. Silica nanoparticles (SNPs) 
      have received wide attention in several industries and medicine and are being 
      developed for biomedical and biotechnological applications such as drug delivery, 
      DNA transfection, and targeted molecular imaging of cancer. Recently, they are 
      emerging in the fields of cosmetics and dermal preparations. SNP may offer a 
      revolutionized treatment of several skin diseases by controlled and sustained 
      release of drugs to skin, as well as enhanced skin penetration of encapsulated 
      drug ingredients. SNPs are candidates for transcutaneous vaccination and 
      transdermal gene therapy, too. Yet there exist concerns that whilst the 
      properties of SNPs have enabled numerous industrial and medical applications, 
      their toxicological and environmental safety mandates evaluation. The knowledge 
      of passage of SNPs through skin following skin exposure (intentionally or 
      unintentionally) and subsequent effects is limited. This review surveys the key 
      experiments on SNP-based formulations in the fields of dermatology and cosmetics 
      with the goal of rationalizing data and informing public health concerns related 
      to SNPs' toxicity among scientists and manufacturers handling them, while 
      highlights the research gaps in dermal absorption of these compounds.
FAU - Nafisi, Shohreh
AU  - Nafisi S
AD  - Department of Dermatology, University of California , San Francisco, CA , USA 
      and.
FAU - Schafer-Korting, Monika
AU  - Schafer-Korting M
FAU - Maibach, Howard I
AU  - Maibach HI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141006
PL  - England
TA  - Nanotoxicology
JT  - Nanotoxicology
JID - 101233132
RN  - 0 (Drug Carriers)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Consumer Product Safety
MH  - Drug Carriers/chemistry/*pharmacokinetics/toxicity
MH  - Humans
MH  - Nanoparticles/*chemistry/toxicity
MH  - Particle Size
MH  - Silicon Dioxide/chemistry/*pharmacokinetics/toxicity
MH  - Skin/anatomy & histology/*drug effects/metabolism
MH  - *Skin Absorption
MH  - Surface Properties
OTO - NOTNLM
OT  - Percutaneous penetration
OT  - silica nanoparticles
OT  - toxicity
EDAT- 2014/10/07 06:00
MHDA- 2016/04/19 06:00
CRDT- 2014/10/07 06:00
PHST- 2014/10/07 06:00 [entrez]
PHST- 2014/10/07 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.3109/17435390.2014.958115 [doi]
PST - ppublish
SO  - Nanotoxicology. 2015;9(5):643-57. doi: 10.3109/17435390.2014.958115. Epub 2014 
      Oct 6.