PMID- 25287443
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20211203
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 93
IP  - 2
DP  - 2015 Feb
TI  - Overexpression of Jagged-1 combined with blockade of CD40 pathway prolongs 
      allograft survival.
PG  - 213-7
LID - 10.1038/icb.2014.84 [doi]
AB  - Dendritic cells (DCs) have the tolerogenic potential to regulate adaptive 
      immunity and induce allografts acceptance. Here we investigated whether blockade 
      of the CD40 pathway could enhance the immune tolerance induced by DC2.4 cells 
      modified to express Jagged-1 (JAG1-DC) in heart transplantation. Results showed 
      that JAG1-DC treatment combined with anti-CD40L monoclonal antibody (mAb) 
      administration significantly prolonged cardiac allograft survival in mice, with 
      long-term survival (>110 days) of 50% of the allografts in the recipients. The 
      therapy specifically inhibited the immune response, induced alloantigen-specific 
      T-cell hyporesponsiveness, upregulated transforming growth factor-beta synthesis and 
      increased the population of regulatory T cells (Tregs) driven by Jagged-1-Notch 
      activation. These results highlight the potential application of gene therapy to 
      induce alloantigen-specific Tregs effectively by providing the Jagged-1 
      stimulation.
FAU - Lin, Yingying
AU  - Lin Y
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Chen, Weili
AU  - Chen W
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Li, Jiali
AU  - Li J
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Yan, Guoliang
AU  - Yan G
AD  - Basic Medical Department of Medical College, Xiamen University, Fujian Province, 
      P.R. China.
FAU - Li, Chun
AU  - Li C
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Jin, Ning
AU  - Jin N
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Chen, Jie
AU  - Chen J
AD  - Basic Medical Department of Medical College, Xiamen University, Fujian Province, 
      P.R. China.
FAU - Gao, Chang
AU  - Gao C
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Ma, Pengfei
AU  - Ma P
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Xu, Shuangyue
AU  - Xu S
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
FAU - Qi, Zhongquan
AU  - Qi Z
AD  - Organ Transplantation Institute, Xiamen University, Fujian Province, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (CD40 Antigens)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Jag1 protein, mouse)
RN  - 0 (Jagged-1 Protein)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Notch)
RN  - 0 (Serrate-Jagged Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Allografts/*immunology
MH  - Animals
MH  - CD40 Antigens/*metabolism
MH  - CD40 Ligand
MH  - Calcium-Binding Proteins/*metabolism
MH  - Cell Line
MH  - Cell Proliferation
MH  - Dendritic Cells/immunology
MH  - Female
MH  - Forkhead Transcription Factors/metabolism
MH  - Graft Survival/*immunology
MH  - Heart Transplantation
MH  - Immunosuppression Therapy
MH  - Inflammation/immunology/pathology
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Jagged-1 Protein
MH  - Lymphocyte Activation/immunology
MH  - Membrane Proteins/*metabolism
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Receptors, Notch/metabolism
MH  - Serrate-Jagged Proteins
MH  - *Signal Transduction
MH  - Spleen/immunology
MH  - T-Lymphocytes/cytology/immunology
MH  - Transforming Growth Factor beta/metabolism
EDAT- 2014/10/08 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/10/08 06:00
PHST- 2014/03/14 00:00 [received]
PHST- 2014/08/25 00:00 [revised]
PHST- 2014/09/03 00:00 [accepted]
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - icb201484 [pii]
AID - 10.1038/icb.2014.84 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2015 Feb;93(2):213-7. doi: 10.1038/icb.2014.84. Epub 2014 Oct 
      7.