PMID- 25287536
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2190-5215 (Print)
VI  - 10
DP  - 2015
TI  - Involvement of Nitric Oxide, Neurotrophins and HPA Axis in Neurobehavioural 
      Alterations Induced by Prenatal Stress.
PG  - 61-74
LID - 10.1007/978-1-4939-1372-5_4 [doi]
AB  - Several studies suggest that negative emotions during pregnancy generate adverse 
      effects on the cognitive, behavioural and emotional development of the 
      descendants. The psychoneuroendocrine pathways involve the transplacentary 
      passage of maternal glucocorticoids in order to influence directly on fetal 
      growth and brain development.Nitric oxide is a gaseous neurotransmitter that 
      plays an important role in the control of neural activity by diffusing into 
      neurons and participates in learning and memory processes. It has been 
      demonstrated that nitric oxide is involved in the regulation of corticosterone 
      secretion. Thus, it has been found that the neuronal isoform of nitric oxide 
      synthase (nNOS) is an endogenous inhibitor of glucocorticoid receptor (GR) in the 
      hippocampus and that nNOS in the hippocampus may participate in the modulation of 
      hypothalamic-pituitary-adrenal axis activity via GR.Neurotrophins are a family of 
      secreted growth factors consisting of nerve growth factor (NGF), brain-derived 
      neurotrophic factor (BDNF), neurotrophin 3 (NT3) and NT4. Although initially 
      described in the nervous system, they regulate processes such as cell survival, 
      proliferation and differentiation in several other compartments. It has been 
      demonstrated that the NO-citrulline cycle acts together with BDNF in maintaining 
      the progress of neural differentiation.In the present chapter, we explore the 
      interrelation between nitric oxide, glucocorticoids and neurotrophins in brain 
      areas that are key structures in learning and memory processes. The participation 
      of this interrelation in the behavioural and cognitive alterations induced in the 
      offspring by maternal stress is also addressed.
FAU - Maur, Damian G
AU  - Maur DG
AD  - Department of Pharmacology, School of Medicine, University of Buenos Aires, 
      Buenos Aires, Argentina.
FAU - Pascuan, Cecilia G
AU  - Pascuan CG
FAU - Genaro, Ana M
AU  - Genaro AM
FAU - Zorrilla-Zubilete, Maria A
AU  - Zorrilla-Zubilete MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Neurobiol
JT  - Advances in neurobiology
JID - 101571545
SB  - IM
EDAT- 2014/10/08 06:00
MHDA- 2014/10/08 06:01
CRDT- 2014/10/08 06:00
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2014/10/08 06:01 [medline]
AID - 10.1007/978-1-4939-1372-5_4 [doi]
PST - ppublish
SO  - Adv Neurobiol. 2015;10:61-74. doi: 10.1007/978-1-4939-1372-5_4.